Prognostic value of circulating biomarker score in advanced-stage head and neck squamous cell carcinoma.

Abstract

BACKGROUND:

Circulating biomarker (CB) is a convenient, emerging predictive tool for treatment response and outcomes in human cancers. Therefore, we examined the prognostic value of pre-treatment and early post-treatment CBs and their summated scores in patients with head and neck squamous cell carcinoma (HNSCC).

METHODS:

This study prospectively included 310 consecutive patients who underwent definitive treatment for previously untreated advanced-stage HNSCC between 2010 and 2015. The CB score was determined by complete blood counts (CBCs) and blood chemistry before and 2 months after the treatment, and the number of abnormal CB was counted from 0 to 10. Univariate and multivariate analyses with Cox proportional hazards models were used to find factors associated with disease-free survival (DFS) and overall survival (OS).

RESULTS:

Most CBC profiles were significantly changed at 2-months post-treatment compared with those at pre-treatment. Univariate analyses showed that hypoalbuminemia, leucocytosis, C-reactive protein, high CB scores (≥6), age, performance status and comorbidity and tumour site were significantly associated with DFS and OS (all P < 0.05). Both pre- and post-treatment CB scores were independent factors predictive of DFS and OS outcomes in the multivariate analyses (P < 0.05). High CB scores at pre-treatment were associated with 7-10-fold increased risk of unfavourable DFS and OS outcomes, and those at 2-months post-treatment were associated with 2 to 4-fold increased risk of poor survival outcomes (all P < 0.05).

CONCLUSIONS:

CB scores at pre-treatment and early post-treatment are useful for predicting survival outcomes in patients with advanced-stage HNSCC.

• Authors: Marn Joon Park, Jong-Lyel Roh, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 92 Pg. 69-76 (03 2018) ISSN: 1879-0852 [Electronic] England
• PMID: 29428866 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Biomarkers, Tumor

Topics

• Aged
• Biomarkers, Tumor (blood)
• Carcinoma, Squamous Cell (blood, mortality, pathology, therapy)
• Disease-Free Survival
• Female
• Head and Neck Neoplasms (blood, mortality, pathology, therapy)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Staging
• Predictive Value of Tests
• Proportional Hazards Models
• Prospective Studies
• Reproducibility of Results
• Risk Factors
• Squamous Cell Carcinoma of Head and Neck
• Time Factors
• Treatment Outcome