[Development of "Patient Friendly Formulations" to Counter the Side Effects of Cancer Chemotherapy].

Abstract

　Anticancer drug-induced stomatitis develops in 30% to 40% of cancer patients undergoing chemotherapy. However, medications for this condition are not commercially available in Japan. The "hospital formulation" is a customized medicine which hospital pharmacists prepare when doctors cannot carry out the medical therapy most suitable for a patient using commercial medicines. However, as the duties of pharmacists increase, use of the "hospital fomulation" decreases. Therefore, development of "hospital fomulations" based on individual evidence has a limit. Irsogladine maleate (IM) is a drug with gastric mucosal protective properties. IM increases intracellular cAMP levels in the gastric mucosa and activates communication between cells. It has been reported that the oral administration of IM reduces the incidence of 5-FU-based chemotherapy-induced stomatitis. However, there have been no reports on the effect of the direct use of IM in treating stomatitis. Therefore, we studied the development of an IM oral spray for stomatitis treatment, and obtained evidence of a direct effect in an animal experiment using a stomatitis model. Next, rebamipide mouthwash was administered to patients who had stomatitis caused by cancer chemotherapy. The total scores were classified into Grades 0 to 4 and evaluated as a stomatitis evaluation score (SES). When comparing SES and changes in the stomatitis area in patients, gradual reductions in the extent of stomatitis were observed, even during the period when SES did not change. Having patients fill in an observation chart was effective for grasping changes in symptoms in outpatients.

• Authors: Takehisa Hanawa, Yayoi Kawano, Mitsutoshi Satoh
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 138 Issue 2 Pg. 169-175 ( 2018) ISSN: 1347-5231 [Electronic] Japan
• PMID: 29386430 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Mouthwashes
• Quinolones
• Triazines
• Cyclic AMP
• rebamipide
• Alanine
• irsogladine

Topics

• Administration, Oral
• Alanine (administration & dosage, analogs & derivatives)
• Animals
• Antineoplastic Agents (adverse effects)
• Cell Communication (drug effects)
• Cyclic AMP (metabolism)
• Disease Models, Animal
• Drug Compounding
• Evidence-Based Medicine
• Gastric Mucosa (cytology, metabolism)
• Humans
• Mouthwashes
• Quinolones (administration & dosage)
• Stomatitis (chemically induced, drug therapy, prevention & control)
• Treatment Outcome
• Triazines (administration & dosage, pharmacology)