Abstract | OBJECTIVE: SETTING AND PARTICIPANTS: Nested cohort of all Medicare beneficiaries 65 years of age and older who survived a traumatic brain injury (TBI) hospitalization during 2006 through 2010. The final sample comprised 100 515 beneficiaries. DESIGN: Retrospective cohort study of older Medicare beneficiaries. Relative risks (RR) and 95% confidence interval (CI) were obtained using discrete time analysis and generalized estimating equations. MEASURES: RESULTS:
Statin use of any kind was associated with decreased mortality following TBI hospitalization discharge. Any statin use was also associated with a decrease in any stroke (RR, 0.86; 95% confidence intervals (CI), 0.81-0.91), depression (RR, 0.85; 95% CI, 0.79-0.90), and Alzheimer's disease and related dementias (RR, 0.77; 95% CI, 0.73-0.81). CONCLUSION: These findings provide valuable information for clinicians treating older adults with TBI as clinicians can consider, when appropriate, atorvastatin and simvastatin to older adults with TBI in order to decrease mortality and associated morbidities.
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Authors | Bilal Khokhar, Linda Simoni-Wastila, Julia F Slejko, Eleanor Perfetto, Min Zhan, Gordon S Smith |
Journal | The Journal of head trauma rehabilitation
(J Head Trauma Rehabil)
2018 Nov/Dec
Vol. 33
Issue 6
Pg. E68-E76
ISSN: 1550-509X [Electronic] United States |
PMID | 29385012
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Topics |
- Aged
- Aged, 80 and over
- Brain Injuries, Traumatic
(epidemiology)
- Cohort Studies
- Dementia
(epidemiology)
- Depression
(epidemiology)
- Female
- Hospitalization
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Male
- Medicare
- Retrospective Studies
- Stroke
(epidemiology)
- Survivors
- United States
(epidemiology)
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