Four new C19-diterpenoid alkaloids from Delphinium elatum.

Abstract

Diterpenoid alkaloids with remarkable chemical properties and biological activities are frequently found in plants of the genera Aconitum, Delphinium, and Garrya. Accordingly, several C19-diterpenoid alkaloid components from Delphinium elatum cv. Pacific Giant, as well as their derivatives, exhibited cytotoxic activity against lung, prostate, nasopharyngeal, and vincristine-resistant nasopharyngeal cancer cell lines. Four new C19-diterpenoid alkaloids, elapacigine (1), N-deethyl-N-formylpaciline (2), N-deethyl-N-formylpacinine (3), and N-formyl-4,19-secoyunnadelphinine (4), together with 11 known C19-diterpenoid alkaloids were isolated in a phytochemical investigation on the seeds of D. elatum cv. Pacific Giant. Their structures were elucidated by extensive spectroscopic methods including NMR (1D and 2D), IR, and MS (HRMS). Three of the new C19-diterpenoid alkaloids (2-4) and five of the known diterpenoid alkaloids were evaluated for cytotoxic activity against five human tumor cell lines.

• Authors: Hiroshi Yamashita, Megumi Katoh, Akane Kokubun, Ayano Uchimura, Sakina Mikami, Ayana Takeuchi, Kyousuke Kaneda, Yuji Suzuki, Megumi Mizukami, Masuo Goto, Kuo-Hsiung Lee, Koji Wada
• Journal: Phytochemistry letters (Phytochem Lett) Vol. 24 Pg. 6-9 (Apr 2018) ISSN: 1874-3900 [Print] Netherlands
• PMID: 29375725 (Publication Type: Journal Article)