[Analysis of the bone anabolic agent by intravital imaging technique.]

Abstract

Teriparatide, recombinant human PTH(1-34), is the only anabolic agent widely used for osteoporosis. This drug is thought to promote bone formation by modulating bone remodeling system, although the detailed mechanism remains unclear. Recently, we developed a novel intravital imaging technique to visualize mature osteoclasts and mature osteoblasts simultaneously. By means of this system, we revealed the effect of teriparatide on three-dimensional distribution and cell-to-cell interactions between these cells. Advances in these imaging studies may lead to further understanding of the intercellular network in bone metabolism.

• Authors: Akito Morimoto, Junichi Kikuta, Masayuki Furuya, Masaru Ishii
• Journal: Clinical calcium (Clin Calcium) 2018 Vol. 28 Issue 2 Pg. 243-248 ISSN: 0917-5857 [Print] Japan
• PMID: 29371491 (Publication Type: Journal Article)

Chemical References

• Anabolic Agents

Topics

• Anabolic Agents (pharmacology)
• Animals
• Bone Remodeling
• Bone and Bones (cytology, drug effects, physiology)
• Humans
• Intravital Microscopy
• Osteoblasts (drug effects)
• Osteoclasts (drug effects)