Abstract | OBJECTIVE: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. METHODS: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. RESULTS: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p<0.05). Based on the parental reports, only the physical and total scores were significantly lower in autoimmune hepatitis patients versus controls (p<0.05). Further analysis in autoimmune hepatitis patients with abdominal pain in the last month revealed significantly lower physical, social, and total median scores (p<0.05). No differences were observed based on disease remission state or disease severity (p>0.05). Autoimmune hepatitis patients who received a prednisone dose below 0.16mg/kg/day at the time of the interview showed significantly higher physical scores than those who received a dose similar to or above 0.16mg/kg/day (87.5 [50-100] vs. 75 [15.63-100], p=0.006). CONCLUSIONS:
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Authors | Ana Beatriz Bozzini, Luciana Neder, Clovis A Silva, Gilda Porta |
Journal | Jornal de pediatria
(J Pediatr (Rio J))
2019 Jan - Feb
Vol. 95
Issue 1
Pg. 87-93
ISSN: 1678-4782 [Electronic] Brazil |
PMID | 29331407
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved. |
Chemical References |
- Glucocorticoids
- Prednisone
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Topics |
- Adolescent
- Case-Control Studies
- Child
- Child, Preschool
- Cross-Sectional Studies
- Female
- Glucocorticoids
(administration & dosage)
- Hepatitis, Autoimmune
(drug therapy, psychology)
- Humans
- Male
- Prednisone
(administration & dosage)
- Quality of Life
(psychology)
- Remission Induction
- Severity of Illness Index
- Surveys and Questionnaires
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