Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells.

Abstract	Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 overexpression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.
Authors	Jia Ouyang, Hui Xu, Ming Li, Xingliang Dai, Fengqing Fu, Xueguang Zhang, Qing Lan
Journal	Oncology reports (Oncol Rep) Vol. 39 Issue 3 Pg. 1052-1062 (Mar 2018) ISSN: 1791-2431 [Electronic] Greece
PMID	29286139 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Biomarkers, Tumor Glucosides Monoterpenes S-Phase Kinase-Associated Proteins peoniflorin
Topics	Animals Anti-Inflammatory Agents, Non-Steroidal (pharmacology) Apoptosis (drug effects) Biomarkers, Tumor (metabolism) Brain Neoplasms (drug therapy, enzymology, pathology) Cell Cycle (drug effects) Cell Proliferation (drug effects) Female Glioma (drug therapy, enzymology, pathology) Glucosides (pharmacology) Humans Mice Mice, Nude Monoterpenes (pharmacology) S-Phase Kinase-Associated Proteins (antagonists & inhibitors, metabolism) Tumor Cells, Cultured Xenograft Model Antitumor Assays

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