Safety and Efficacy of Losartan 50 mg in Reducing Blood Pressure among Patients with Post-Dialysis Euvolemic Hypertension: A Randomized Control Trial.

Abstract

The aim of current study was to assess the effectiveness of losartan 50 mg in reducing blood pressure among post-dialysis euvolemic hypertensive patients, observing their survival trends and adverse events during the course of study. A multicentre, prospective, randomised, single-blind trial was conducted to assess the effect of losartan 50 mg every other day (EOD), once a morning (OM) among post-dialysis euvolemic hypertensive patients. Post-dialysis euvolemic assessment was done by a body composition monitor (BCM). Covariate Adaptive Randomization was used for allocation of participants to the standard or intervention arm. Of the total 229 patients, 96 (41.9%) were identified as post-dialysis euvolemic hypertensive. Final samples of 88 (40.1%) patients were randomized into standard and intervention arms. After follow-up of 12 months' pre-dialysis systolic (p < 0.001) and diastolic (p 0.01), intradialysis diastolic (p 0.02), post-dialysis systolic (p < 0.001) and diastolic (p < 0.001) blood pressure was reduced from the baseline among intervention-arm patients Compared to only pre-dialysis systolic blood pressure (p 0.003) among standard arm patients after 12 months of follow. Total of six deaths were reported among standard-arm patients compared to 2 deaths among the intervention arm. Losartan 50 mg achieve an overall significant decline in blood pressure among post-dialysis euvolemic hypertensive patients.

• Authors: Raja Ahsan Aftab, Amer Hayat Khan, Azreen Syazril Adnan, Syed Azhar Syed Sulaiman, Tahir Mehmood Khan
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 17741 (12 18 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 29255272 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Angiotensin II Type 1 Receptor Blockers
• Antihypertensive Agents
• Losartan

Topics

• Adult
• Aged
• Angiotensin II Type 1 Receptor Blockers (pharmacology)
• Antihypertensive Agents (pharmacology)
• Blood Pressure (drug effects)
• Female
• Humans
• Hypertension (drug therapy, physiopathology)
• Losartan (pharmacology, therapeutic use)
• Male
• Middle Aged
• Prospective Studies
• Renal Dialysis (adverse effects)
• Single-Blind Method
• Systole (drug effects)
• Treatment Outcome