A Novel Multifactorial Approach to Developing Mild Laundry Detergents and Assessing Their Relative Mildness

Abstract

INTRODUCTION: Dermatologists are becoming more aware of the irritant and allergic potential of laundry detergents that incorporate harsh surfactants and potentially sensitizing ingredients. It is difficult however for the physician to distinguish one laundry detergent from another because the only distinguishing feature advertised tends to be the lack of dyes and fragrances. DESIGN: A new objective method was developed for measuring the harshness of laundry detergents using a three-pronged laboratory testing approach consisting of zein, corneosurfametry, and cytokine testing. Combing these methods, a Detergent Mildness Index was created which conveniently provides a single value by which products can be compared. RESULTS: A new mild laundry detergent was formulated with ingredients carefully selected by dermatologists who are experts in con-tact dermatitis. The irritancy potential of the formula was measured using the Detergent mildness index score. Compared to 11 other commercial laundry detergents marketed for sensitive skin, the new formula is measurably the mildest formula. DISCUSSION: The Detergent Mildness Index provides dermatologists with an objective method to compare commercial laundry deter-gents. Currently the only method available is patch testing, this new test is able to more finely differentiate between products and thus enables more informed recommendations on laundry detergent choices for their patients with sensitive skin.

• Authors: Joseph F Fowler Jr, Matthew J Zirwa J Zirwas, Lisa Napolitano, Meghan Russell, Janet Coope-Epstein
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 16 Issue 12 Pg. 1235-1239 (12 01 2017) ISSN: 1545-9616 [Print] United States
• PMID: 29240858 (Publication Type: Journal Article)

Chemical References

• Detergents
• Irritants
• Surface-Active Agents

Topics

• Dermatitis, Allergic Contact (etiology, prevention & control)
• Detergents (adverse effects, chemistry)
• Humans
• Irritants (adverse effects, chemistry)
• Patch Tests (methods)
• Surface-Active Agents (adverse effects, chemistry)