Prognostic factors in patients with skeletal-related events at non-small-cell lung cancer diagnosis.

Abstract

The aim of the present study was to detect prognostic factors in patients with skeletal-related events (SREs) and bone metastasis at the time of non-small-cell lung cancer (NSCLC) diagnosis. A total of 85 NSCLC patients were retrospectively enrolled, 47 (55.2%) of whom presented with SREs at the time of NSCLC diagnosis. Multivariate logistic regression analysis identified squamous cell carcinoma as a risk factor for SRE. Kaplan-Meier analysis demonstrated that there was no difference in the overall survival between the SRE and no SRE groups. Cox hazard model revealed that a higher Eastern Cooperative Oncology Group (ECOG) performance status (PS) score was a risk factor for poor prognosis, while surgery for bone metastasis and molecular-targeted therapy were factors for better prognosis in patients with SREs at the time of NSCLC diagnosis. Multivariate analysis revealed that a higher ECOG PS score and metastasis to the adrenal gland were risk factors for poor prognosis, while surgery for bone metastasis and molecular-targeted therapy were factors for better prognosis. Thus, while surgical treatment and molecular-targeted therapy appear to improve the prognosis of patients with bone metastasis at the time of NSCLC diagnosis, those with a higher ECOG PS score and adrenal metastasis may benefit more from radiotherapy or supportive care.

• Authors: Hiroyuki Tominaga, Takao Setoguchi, Hirofumi Shimada, Satoshi Nagano, Hiromi Sasaki, Yasuhiro Ishidou, Masami Sato, Keiko Mizuno, Hiromasa Inoue, Setsuro Komiya
• Journal: Molecular and clinical oncology (Mol Clin Oncol) Vol. 7 Issue 5 Pg. 897-902 (Nov 2017) ISSN: 2049-9450 [Print] England
• PMID: 29181185 (Publication Type: Journal Article)