First-line antibiotic therapy in Helicobacter pylori-negative low-grade gastric mucosa-associated lymphoid tissue lymphoma.

Abstract

First-line antibiotic treatment for eradicating Helicobacter pylori (HP) infection is effective in HP-positive low-grade gastric mucosa-associated lymphoid tissue lymphoma (MALToma), but its role in HP-negative cases is uncertain. In this exploratory retrospective study, we assessed the outcome and potential predictive biomarkers for 25 patients with HP-negative localized gastric MALToma who received first-line HP eradication (HPE) therapy. An HP-negative status was defined as negative results on histology, rapid urease test, 13C urea breath test, and serology. We observed an antibiotic response (complete remission [CR], number = 8; partial remission, number = 1) in 9 (36.0%) out of 25 patients. A t(11;18)(q21;q21) translocation was detected in 7 (43.8%) of 16 antibiotic-unresponsive cases, but in none of the 9 antibiotic-responsive cases (P = 0.027). Nuclear BCL10 expression was significantly higher in antibiotic-unresponsive tumors than in antibiotic-responsive tumors (14/16 [87.5%] vs. 1/9 [11.1%]; P = 0.001). Nuclear NF-κB expression was also significantly higher in antibiotic-unresponsive tumors than in antibiotic-responsive tumors (12/16 [75.0%] vs. 1/9 [11.1%]; P = 0.004). A substantial portion of patients with HP-negative gastric MALToma responded to first-line HPE. In addition to t(11;18)(q21;q21), BCL10 and NF-κB are useful immunohistochemical biomarkers to predict antibiotic-unresponsive status in this group of tumors.

• Authors: Sung-Hsin Kuo, Kun-Huei Yeh, Ming-Shiang Wu, Chung-Wu Lin, Ming-Feng Wei, Jyh-Ming Liou, Hsiu-Po Wang, Li-Tzong Chen, Ann-Lii Cheng
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 14333 (10 30 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 29084984 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Antineoplastic Agents
• B-Cell CLL-Lymphoma 10 Protein
• BCL10 protein, human
• NF-kappa B

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• B-Cell CLL-Lymphoma 10 Protein (genetics, metabolism)
• Drug Resistance, Neoplasm (genetics)
• Female
• Gastric Mucosa (pathology)
• Gene Expression Regulation, Neoplastic
• Helicobacter pylori (physiology)
• Humans
• Lymphoid Tissue (pathology)
• Lymphoma (drug therapy)
• Male
• Middle Aged
• NF-kappa B (genetics, metabolism)
• Stomach Neoplasms (drug therapy)
• Treatment Outcome
• Young Adult