The efficacy of probucol combined with hydration in preventing contrast-induced nephropathy in patients with coronary heart disease undergoing percutaneous coronary intervention: a multicenter, prospective, randomized controlled study.

Abstract

PURPOSE:

To investigate the preventive effect of probucol combined with hydration on contrast-induced nephropathy (CIN) in patients with coronary heart disease undergoing percutaneous coronary intervention (PCI).

METHODS:

A total of 641 patients undergoing PCI were randomly assigned to either a probucol group (probucol 500 mg twice daily and hydration; n = 321) or a control group (hydration only; n = 320). The primary endpoint was the incidence of CIN, defined as an increase in serum creatinine (Scr) by ≥ 44.2 μmol/L or ≥ 25% within 72 h after the administration of contrast agent. Secondary endpoints were changes in Scr, cystatin-C (Cys-C), creatinine clearance rate (Ccr), C-reactive protein (CRP), superoxide dismutase (SOD), and glutathione (GSH) within 72 h, and major adverse events during hospitalization or the 14-day follow-up period.

RESULTS:

The incidence of CIN was 4.0% (13/321) in the probucol group and 10.9% (35/320) in the control group. The probucol group had lower Cys-C and higher Ccr at 48 and 72 h after PCI compared with the control group. At 48 and 72 h following the operation, Cys-C and CRP were lower in the probucol group compared with the control group, but Ccr, SOD, and GSH were higher. There were no differences in the incidence of major adverse events during hospitalization or the 14-day follow-up between the groups. Multivariate logistic regression analysis showed that probucol was an independent protective factor for CIN.

CONCLUSIONS:

Probucol combined with hydration more effectively decreased the incidence of CIN in patients with coronary heart disease undergoing PCI compared with hydration alone.

• Authors: Naikuan Fu, Shicheng Yang, Jing Zhang, Peng Zhang, Min Liang, Hongliang Cong, Wenhua Lin, Fengshi Tian, Chengzhi Lu
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 50 Issue 1 Pg. 105-112 (Jan 2018) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 29071556 (Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Contrast Media
• Cystatin C
• Creatinine
• Superoxide Dismutase
• Glutathione
• Probucol

Topics

• Aged
• Antioxidants (therapeutic use)
• Combined Modality Therapy
• Contrast Media (adverse effects)
• Coronary Disease (complications, surgery)
• Creatinine (blood, urine)
• Cystatin C (blood)
• Female
• Fluid Therapy
• Glutathione (blood)
• Heart Failure (etiology)
• Hemorrhage (etiology)
• Humans
• Kidney Diseases (blood, chemically induced, prevention & control)
• Male
• Middle Aged
• Percutaneous Coronary Intervention (adverse effects)
• Probucol (therapeutic use)
• Prospective Studies
• Protective Factors
• Stroke (etiology)
• Superoxide Dismutase (blood)