[Efficacy Analysis of GEMOX Regimen for Treatment of Refractory Non-Hodgkin's Lymphoma].

Abstract

OBJECTIVE:

To explore the clinical efficacy of GEMOX regimen on patients with refractory non-hodgkin's lymphoma.

METHODS:

Eighty-two cases of non-Hodgkin's lymphoma were divided into 2 groups: gemcitabine+oxaliplation(Gem+Oxa) group (42 cases) and vinorelbine+oxaliplatin(Vin+Oxa) group (40 cases) according to chemotherapy regimens. The clinical efficacy, side effects, progression-free survival situation in 2 groups were compared.

RESULTS:

There was no significant difference on the clinical effects of 2 groups (P>0.05); The therapeutic efficacy for B cell lymphoma was higher than that for T cell lymphoma(P<0.05); The therapeutic effects for I-II stages was lower than that for III-IV stages(P<0.05); The incidences of platelet decline, nausea and vomit, peripheral nerve symptoms in Gem+Oxa group were lower than those in Vin+Oxa group(P<0.05); There was no significant difference in the median progression free survival(P>0.05).

CONCLUSION:

The efficacy of GEMOX regimen for refractory non-Hodgkin's lymphoma has been confirmed to be good, it has distinct clinical curative effect, it can prolong the progression-free survival time in patients with B cell lymphoma, specially for III-IV stages. It can be used as the preferred method for the treatment of patients with refractory NHL.

• Authors: Shi-Bin Yan, Zhong-Guang Chen, De-Liang Ma, Xin Lyu, Yan-Li Wang, Shi-Bing Chen, Gui-Tao Jie
• Journal: Zhongguo shi yan xue ye xue za zhi (Zhongguo Shi Yan Xue Ye Xue Za Zhi) Vol. 25 Issue 5 Pg. 1415-1419 (Oct 2017) ISSN: 1009-2137 [Print] China
• PMID: 29070117 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Organoplatinum Compounds
• Oxaliplatin
• Deoxycytidine
• Vinblastine
• Vinorelbine

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Disease-Free Survival
• Humans
• Lymphoma, B-Cell
• Lymphoma, Non-Hodgkin (drug therapy)
• Organoplatinum Compounds (administration & dosage)
• Oxaliplatin
• Treatment Outcome
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine