Multiple anthelmintic resistance in Southern Brazil sheep flocks.

Abstract

Gastrointestinal parasites represent an important cause of reduced productivity of sheep worldwide. As anthelmintic are still the main control tool for these parasites, this work evaluated the efficacy of commercially available active principles in 22 sheep flocks in the southern region of Rio Grande do Sul, Brazil. In each farm 10 sheep were randomly distributed in seven groups with the following treatments: abamectin; albendazole; closantel; levamisole; monepantel; trichlorphon and no anthelmintic (control). All flocks showed resistance to at least three anthelmintics and in 20 farms only two products demonstrated efficacy for parasitic control. In two farms, there was no susceptibility to the six active principles tested. The results of this study provide evidence that the common commercially available anthelmintic are not assuring effective chemical control of gastrointestinal parasitic infections in ovine flocks in the southern region of Rio Grande do Sul. Monepantel, the newest introduced drug in the Brazilian market was not effective in 18% of the flocks tested, confirming that the parasitic resistance can be established quickly after the introduction of new molecules mainly when alternative program of parasite control is not performed.

• Authors: Plínio Aguiar de Oliveira, Beatriz Riet-Correa, Pablo Estima-Silva, Ana Carolina Barreto Coelho, Bianca Lemos Dos Santos, Marco André Paldês Costa, Jerônimo Lopes Ruas, Ana Lucia Schild
• Journal: Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria (Rev Bras Parasitol Vet) 2017 Oct-Dec Vol. 26 Issue 4 Pg. 427-432 ISSN: 1984-2961 [Electronic] Brazil
• PMID: 29069158 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anthelmintics

Topics

• Animals
• Anthelmintics (therapeutic use)
• Brazil
• Drug Resistance, Multiple
• Helminthiasis, Animal (drug therapy)
• Sheep
• Sheep Diseases (drug therapy, parasitology)