Trichlorfon (Metrifonate)

A organochlorophosphate cholinesterase inhibitor that is used as an insecticide for the control of flies and roaches. It is also used in anthelmintic compositions for animals. (From Merck, 11th ed)

Also Known As:

Networked: 345 relevant articles (36 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cyrus, P A: 4 articles (01/2001 - 01/2000)
2.	Pohanka, Miroslav: 3 articles (10/2011 - 06/2009)
3.	Bhushan, Chandra: 3 articles (08/2011 - 12/2009)
4.	Fiel, César: 2 articles (08/2011 - 08/2011)
5.	Guzmán, Maricel: 2 articles (08/2011 - 08/2011)
6.	Steffan, Pedro: 2 articles (08/2011 - 08/2011)
7.	Prieto, Olegario: 2 articles (08/2011 - 08/2011)
8.	Schmid, E: 2 articles (05/2011 - 01/2000)
9.	Rozas, Carlos: 2 articles (07/2009 - 12/2007)
10.	Pancetti, Floria: 2 articles (07/2009 - 12/2007)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/1998 - "A pilot study, and Phase I and Phase II studies of metrifonate in Alzheimer's disease (AD) patients conducted prior to the current study showed benign, dose-dependent adverse event profiles consisting primarily of gastrointestinal events, optimal daily dosing with a loading phase (in the absence of a loading dose phase, 6-8 weeks were required to attain steady-state AChE inhibition levels), and an improvement in Alzheimer's Disease Assessment Scale (ADAS) scores. " 05/01/1998 - "Metrifonate significantly improved cognitive ability, as assessed by the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and enhanced global function, as assessed the Clinicians's Interview-Based Impression of Change with Caregiver Input (CIBIC-Plus). " 01/01/1998 - "Therefore, metrifonate is a useful treatment for the symptoms of Alzheimer's disease." 01/01/1999 - "This prospective, randomized, double-masked, placebo-controlled, parallel-group study assessed the safety and efficacy of 2 dosage regimens of once-daily metrifonate in patients with probable Alzheimer's disease (AD) of mild-to-moderate severity. " 01/01/2001 - "Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimer's disease."
2.	Infection 09/01/1991 - "haematobium infections compared with metrifonate and more effective in treating S. " 07/01/1985 - "During the study period 25% of children with no evidence of infection at the start of the trial had become infected, while 45.5% of children apparently cured by the metrifonate treatment had recommenced egg excretion. " 01/01/1987 - "We have carried out an open clinical study in Somalia to evaluate the efficacy and safety of a simplified dosage schedule of metrifonate in the treatment of Schistosoma haematobium infection. " 04/15/2013 - "From these results, we concluded that immunological responses and immune gene expressions of prawn exposed to trichlorfon at 0.4mgL(-1) for 24h were perturbed, thus causing a deficiency in immunity and subsequent increased susceptibility to pathogen infections." 05/01/1998 - "Medications, which can be used to prevent the infection or kill the parasite include praziquante and metrifonate."
3.	Schistosomiasis haematobia (Schistosomiasis haematobium) 01/01/1988 - "Efficacy of metrifonate in a highly endemic area of urinary schistosomiasis in Kenya." 11/01/1982 - "Efficacy of metrifonate in urinary schistosomiasis: comparison of reduction of Schistosoma haematobium and S. " 11/01/2009 - "The review confirmed that both the standard recommended doses of PZQ (single 40 mg/kg oral dose) and metrifonate (3x7.5-10 mg/kg oral doses administered fortnightly) are efficacious and safe in treating urinary schistosomiasis, but there is no study comparing these two regimens head-to-head. " 06/01/1991 - "During 1989 a survey for urinary schistosomiasis was carried out in children attending Kanhukamwe primary school where, 5 years previously, infected children had been treated with a single dose of metrifonate. " 06/01/1991 - "Long-term effects of single-dose metrifonate on the control of urinary schistosomiasis in an endemic area."
4.	Body Weight (Weight, Body) 01/01/2006 - "Metrifonate at various doses, fixed and loading doses, was associated with significant cognitive improvement compared to placebo, except for weekly doses where there was no difference from placebo: MMSE (metrifonate 60-80 mg/day with initial loading at 26 weeks; metrifonate 50 mg/day fixed dose with no initial loading at 26 weeks MD 1.85, 95% CI 1.06 to 2.64, p<0.00001); ADAS-Cog (metrifonate 60-80 mg/day with initial loading at 26 weeks MD -3.24, 95% CI -4.40 to -2.08, p<0.00001)In most trials, there was improvement in clinical global impression: CIBIC-Plus (metrifonate 30-55 mg/day, approximately 0.65 mg/kg body weight, with initial loading at 26 weeks MD -0.25, 95% CI -0.41 to -0.09 p=0.002; metrifonate 50 mg/day fixed dose with no initial loading at 26 weeks MD -0.20, 95% CI -0.39 to -0.01, p=0.04). " 04/01/1984 - "Thus, trichlorfon given three or four times in a dose of 10 mg/kg of body weight spaced over a period of two years was highly effective in reducing parasite load and disease in children living under hyperendemic conditions." 03/01/2007 - "The pesticide trichlorfon (125 mg/kg on days 42-44 in gestation) gives hypoplasia of the brain of the offspring without any significant reduction in their body weights. " 10/01/2011 - "Wistar rats (six per group) were exposed subcutaneously to either 60 or 120 mg/kg of body weight of metrifonate and compared with the controls treated with saline only. " 07/01/2009 - "The lack of effects of trichlorfon on any in vivo reproductive and fetuses endpoints above suggested that for trichlorfon, a hazard of reproductive toxicity below 50 mg/kg body weight/d maybe not expected. "
5.	Schistosomiasis (Bilharziasis) 07/01/1985 - "In view of this, single dose metrifonate may be a useful approach to mass treatment in a schistosomiasis control program, resulting in significant reduction in egg excretion in those most likely to be important sources of transmission." 01/01/1981 - "The chronology of the clinical trials with metrifonate is described: the first phase where independently of Bayer use was made of the veterinary product, the second phase representing the work done in collaboration with WHO to confirm the correct indication (schistosomiasis due to S. " 01/01/1965 - "Studies on the use of an organophosphorus compound "Dipterex" in the treatment of urinary bilharziasis." 03/12/1997 - "Metrifonate is an organophosphorous compound that has been used in the treatment of schistosomiasis. " 02/01/1997 - "Metrifonate (MTF) is an organophosphorus compound that has been used in the treatment of schistosomiasis. "

Related Drugs and Biologics

1.	Praziquantel (Biltricide)
2.	Cholinesterases (Cholinesterase)
3.	Acetylcholinesterase
4.	donepezil (Aricept)
5.	rivastigmine (Exelon)
6.	Cholinesterase Inhibitors (Anticholinesterases)
7.	Tacrine (Cognex)
8.	Dichlorvos
9.	Thiabendazole (Mintezol)
10.	Cholinergic Agents (Cholinergics)

Related Therapies and Procedures

1.	Activities of Daily Living (ADL)
2.	Drug Therapy (Chemotherapy)
3.	Institutionalization (Institutionalized Persons)
4.	Transplants (Transplant)
5.	Oral Administration