Abstract |
Vascular calcification is a serious complication of chronic kidney disease, but the current therapeutic strategy is insufficient for preventing its progression. Magnesium is a potent inhibitor of calcification and represents a promising therapeutic candidate. Diaz-Tocados and colleagues now demonstrate that magnesium supplementation prevents the progression of vascular calcification in a uremic rat model, independently of the phosphate-binding capacity. We should keep in mind, however, that too much magnesium could have adverse effects on bone metabolism.
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Authors | Naoto Hamano, Hirotaka Komaba, Masafumi Fukagawa |
Journal | Kidney international
(Kidney Int)
Vol. 92
Issue 5
Pg. 1034-1036
(11 2017)
ISSN: 1523-1755 [Electronic] United States |
PMID | 29055421
(Publication Type: Journal Article, Comment)
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Copyright | Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Animals
- Disease Progression
- Humans
- Magnesium
- Phosphates
- Rats
- Renal Insufficiency, Chronic
- Vascular Calcification
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