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Magnesium as a new player in CKD: too little is as bad as too much?

Abstract
Vascular calcification is a serious complication of chronic kidney disease, but the current therapeutic strategy is insufficient for preventing its progression. Magnesium is a potent inhibitor of calcification and represents a promising therapeutic candidate. Diaz-Tocados and colleagues now demonstrate that magnesium supplementation prevents the progression of vascular calcification in a uremic rat model, independently of the phosphate-binding capacity. We should keep in mind, however, that too much magnesium could have adverse effects on bone metabolism.
AuthorsNaoto Hamano, Hirotaka Komaba, Masafumi Fukagawa
JournalKidney international (Kidney Int) Vol. 92 Issue 5 Pg. 1034-1036 (11 2017) ISSN: 1523-1755 [Electronic] United States
PMID29055421 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Phosphates
  • Magnesium
Topics
  • Animals
  • Disease Progression
  • Humans
  • Magnesium
  • Phosphates
  • Rats
  • Renal Insufficiency, Chronic
  • Vascular Calcification

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