Abstract | BACKGROUND: Programmed cell death- ligand 1 (PD-L1) may be a useful molecule for targeted immunotherapy. Therefore, this meta-analysis aimed to investigate PD-L1 expression in breast cancer and its associations with clinicopathological factors and outcomes, which may help determine whether PD-L1 expression is a useful prognostic marker. METHODS: The Medline Ovid, Cochrane, PubMed, Google Scholar, and Web of Knowledge databases were searched for studies that evaluated the prognostic or clinicopathological significance of PD-L1 expression in patients with breast cancer, and reported at least one survival-related outcome. RESULTS: CONCLUSION: The present meta-analysis revealed that cases of breast cancer with PD-L1 positivity in all cells exhibited higher histological grades, lymph node metastasis, and poorer disease-free survival. Therefore, positive expression of PD-L1 may be a useful prognostic marker in breast cancer.
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Authors | Hye Min Kim, Jinae Lee, Ja Seung Koo |
Journal | BMC cancer
(BMC Cancer)
Vol. 17
Issue 1
Pg. 690
(Oct 17 2017)
ISSN: 1471-2407 [Electronic] England |
PMID | 29041905
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- B7-H1 Antigen
- Biomarkers, Tumor
- CD274 protein, human
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Topics |
- Adult
- Aged
- Aged, 80 and over
- B7-H1 Antigen
(genetics)
- Biomarkers, Tumor
(genetics)
- Breast Neoplasms
(diagnosis, metabolism, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Lymphatic Metastasis
- Middle Aged
- Neoplasm Staging
- Prognosis
- Triple Negative Breast Neoplasms
(diagnosis, metabolism)
- Young Adult
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