Calponin 2 plays an important role in regulating actin cytoskeleton, which is critical for cell division and migration. Previous studies have demonstrated that
calponin 2 inhibits
prostate cancer cell proliferation and
metastasis. However, the role of
calponin 2 in pancreatic
tumor growth,
metastasis and patient survival remains unclear. Here, we demonstrate that the level of
calponin 2 is a positive prognostic factor for patients with pancreatic ductal
adenocarcinoma (PDAC). Patients with high
calponin 2 expression in the
tumor presented less
lymph node metastasis and longer survival. Knockdown of
calponin 2 facilitated
pancreatic cancer cell proliferation and
metastasis. Further experiments suggested that PI3K/AKT, NF-κB,
Vimentin,
Fibronectin, Snail and Slug were upregulated and
E-cadherin was downregulated after
calponin 2 was knocked down, implicating altered functions in PDAC proliferation and
metastasis. In addition, we verified that
calponin 2 functioned through inhibiting PI3K/AKT and NF-κB pathways. Our study suggests that the upregulation of
calponin 2 in PDAC correlates to lower
malignancy and presents a novel target for the development of new treatment.