Serum 25-hydroxyvitamin D concentrations and lung cancer risk in never-smoking postmenopausal women.

Abstract

PURPOSE:

Vitamin D has been implicated in lowering lung cancer risk, but serological data on the association among never-smoking women are limited. We report results examining the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with lung cancer risk among female never smokers. We also examined whether the association was modified by vitamin D supplementation and serum vitamin A concentrations.

METHODS:

In the Women's Health Initiative, including the calcium/vitamin D (CaD) Trial, we selected 298 incident cases [191 non-small cell lung cancer (NSCLC) including 170 adenocarcinoma] and 298 matched controls of never smokers. Baseline serum 25(OH)D was assayed by a chemiluminescent method. Logistic regression was used to estimate odds ratios (ORs) for quartiles and predefined clinical cutoffs of serum 25(OH)D concentrations.

RESULTS:

Comparing quartiles 4 versus 1 of serum 25(OH)D concentrations, ORs were 1.06 [95% confidence interval (CI) 0.61-1.84] for all lung cancer, 0.94 (95% CI 0.52-1.69) for NSCLC, and 0.91 (95% CI 0.49-1.68) for adenocarcinoma. Comparing serum 25(OH)D ≥ 75 (high) versus <30 nmol/L (deficient), ORs were 0.76 (95% CI 0.31-1.84) for all lung cancer, 0.71 (95% CI 0.27-1.86) for NSCLC, and 0.81 (95% CI 0.31-2.14) for adenocarcinoma. There is suggestive evidence that CaD supplementation (1 g calcium + 400 IU D3/day) and a high level of circulating vitamin A may modify the associations of 25(OH)D with lung cancer overall and subtypes (p interaction <0.10).

CONCLUSIONS:

In this group of never-smoking postmenopausal women, the results did not support the hypothesis of an association between serum 25(OH)D and lung cancer risk.

• Authors: Ting-Yuan David Cheng, Xiaoling Song, Shirley A A Beresford, Gloria Y F Ho, Karen C Johnson, Mridul Datta, Rowan T Chlebowski, Jean Wactawski-Wende, Lihong Qi, Marian L Neuhouser
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 28 Issue 10 Pg. 1053-1063 (Oct 2017) ISSN: 1573-7225 [Electronic] Netherlands
• PMID: 28900765 (Publication Type: Journal Article)

Chemical References

• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adenocarcinoma (blood, epidemiology)
• Aged
• Carcinoma, Non-Small-Cell Lung (blood, epidemiology)
• Case-Control Studies
• Female
• Humans
• Logistic Models
• Lung Neoplasms (blood, epidemiology)
• Middle Aged
• Odds Ratio
• Postmenopause (blood)
• Risk Factors
• Vitamin D (analogs & derivatives, blood)