Multiple malignant rectal carcinoid tumors with immunocytochemical demonstration of multiple hormonal substances.

Abstract

This case report deals with a patient who presented with 17 small carcinoid tumors of the rectum, the largest measuring less than 1 cm in diameter. After a review of the literature on this subject, this case is believed to be highly unusual in several respects: (1) despite their small size, these tumors resulted in multiple metastases to the regional lymph nodes; (2) both primary tumors and metastases were extensively and strongly argentaffin; and (3) most tumors and metastases contained, when investigated by immunocytochemistry, several biologically active substances such as serotonin, somatostatin, and glucagon-like immunoreactivity.

• Authors: M Kanter, J Lechago
• Journal: Cancer (Cancer) Vol. 60 Issue 8 Pg. 1782-6 (Oct 15 1987) ISSN: 0008-543X [Print] United States
• PMID: 2888527 (Publication Type: Case Reports, Journal Article)

Chemical References

• Serotonin
• Somatostatin
• Glucagon

Topics

• Carcinoid Tumor (metabolism, pathology)
• Glucagon (analysis)
• Humans
• Immunoenzyme Techniques
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasms, Multiple Primary (pathology)
• Rectal Neoplasms (metabolism, pathology)
• Rectum (pathology)
• Serotonin (analysis)
• Somatostatin (analysis)