Genome-Wide Testing of Exonic Variants and Breast Cancer Risk in the California Teachers Study.

Abstract

Background: Few studies have focused on the relationship of exonic variation with breast cancer and subtypes defined by tumor markers: estrogen receptor (ER), progesterone receptor (PR), and HER2.Methods: We genotyped 1,764 breast cancer patients and 1,400 controls from the California Teachers Study cohort using the Infinium HumanExome Beadchip. Individual variant and gene-based analyses were conducted for overall breast cancer and by individual tumor marker subtype.Results: No exonic variants or gene-based analyses were statistically significantly associated with breast cancer overall or by ER-, PR-, or HER2-defined subtype.Conclusions: We did not detect any novel statistically significant exonic variants with overall breast cancer risk or by subtype.Impact: Exonic variants in the exome chip may not be associated with overall breast cancer or subtype susceptibility. Cancer Epidemiol Biomarkers Prev; 26(9); 1462-5. ©2017 AACR.

• Authors: John Charles A Lacson, Huiyan Ma, Eunjung Lee, Susan L Neuhausen, Hoda Anton-Culver, Peggy Reynolds, David O Nelson, Argyrios Ziogas, David Van Den Berg, Dennis M Deapen, Leslie Bernstein, Fredrick R Schumacher
• Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 26 Issue 9 Pg. 1462-1465 (09 2017) ISSN: 1538-7755 [Electronic] United States
• PMID: 28864454 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: ©2017 American Association for Cancer Research.

Topics

• Breast Neoplasms (genetics)
• California
• Case-Control Studies
• Female
• Genetic Variation (genetics)
• Genome-Wide Association Study (methods)
• Humans
• Middle Aged
• Risk