High dietary phosphorus intake is associated with an increased risk of type 2 diabetes in the large prospective E3N cohort study.

Abstract

Phosphorus is an essential nutrient; the adult recommended daily intake ranges from 550 to 700 mg/day, with a tolerated upper limit of 4000 mg/day. Phosphorus intake has increased in the general population in recent years, and simultaneously an alarming rise of type 2 diabetes incidences has been observed. No study has investigated the relationship between phosphorus intake and the risk of type 2 diabetes. To evaluate the association between phosphorus intake and incidence of type 2 diabetes. Among 71,270 women from the French E3N-EPIC cohort, 1845 cases of incident type 2 diabetes were validated during follow-up (1993-2011). Adjusted Cox proportional hazards regression models were used to calculate hazard ratios and 95% confidence intervals (95% CI) for the associations between phosphorus intake and type 2 diabetes risk, adjusted on potential confounders. The overall mean (±SD) phosphorus intake was 1477 mg/day (±391 mg/day). High phosphorus intake was associated with risk of type 2 diabetes. In multivariate models, compared with women in the 1st quartile of phosphorus intake (<1203 mg/day), those included in the 2nd (1203-1434.0 mg/day), 3rd (1434-1700 mg/day), and 4th (>1700 mg/day) were at a higher risk of type 2 diabetes, with a hazards ratios (95% CI) of 1.18 (1.00-1.38), 1.41 (1.20-1.66) and 1.54 (1.25-1.90), respectively. Our results may have important public health implications for dietary recommendations in the prevention of type 2 diabetes. More studies are warranted to better understand the biological mechanisms underlying this positive association.

• Authors: Francesca Romana Mancini, Aurélie Affret, Courtney Dow, Beverley Balkau, Françoise Clavel-Chapelon, Fabrice Bonnet, Marie-Christine Boutron-Ruault, Guy Fagherazzi
• Journal: Clinical nutrition (Edinburgh, Scotland) (Clin Nutr) Vol. 37 Issue 5 Pg. 1625-1630 (10 2018) ISSN: 1532-1983 [Electronic] England
• PMID: 28818343 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Chemical References

• Phosphorus, Dietary

Topics

• Cohort Studies
• Diabetes Mellitus, Type 2 (epidemiology)
• Diet
• Diet, Healthy
• Diet, Western
• Female
• Food Handling
• France (epidemiology)
• Humans
• Middle Aged
• Phosphorus, Dietary (administration & dosage, adverse effects)
• Proportional Hazards Models
• Prospective Studies
• Risk Factors
• Surveys and Questionnaires