Abstract | BACKGROUND: METHODS: RESULTS: Overall, 306 patients (mean age: 66.4 ± 15.0 years) were analysed. During the follow-up period of 2.4 ± 1.2 years, 50 patients (16.3%) died. The dihomo-gamma-linolenic acid (DGLA) levels, arachidonic acid (AA) levels, and DGLA/AA ratio were significantly lower in the nonsurvivor group than in the survivor group (DGLA: 23.2 ± 9.8 vs. 31.5 ± 12.0 μg/ml, AA: 151.1 ± 41.6 vs. 173.3 ± 51.6 μg/ml, and DGLA/AA: 0.16 ± 0.05 vs. 0.19 ± 0.06, all p < 0.01). Kaplan-Meier curves showed that survival rates were significantly higher in the higher DGLA, AA, and DGLA/AA groups than in their lower counterparts (DGLA and AA; p < 0.01, DGLA/AA; p = 0.01), although omega-3 PUFAs were not associated with prognosis. Furthermore, in patients with acute decompensated heart failure (ADHF), survival rates were significantly higher in the higher DGLA, AA, and DGLA/AA groups than in their lower counterparts (DGLA and AA; p < 0.01, DGLA/AA; p = 0.04). However, among patients with acute coronary syndrome, none of the PUFA levels were associated with prognosis. Among patients with ADHF, after controlling for confounding variables, DGLA and DGLA/AA were associated with long-term mortality [DGLA: hazard ratio (HR), 0.94; 95% confidence interval (CI), 0.88-0.99; p = 0.01 and DGLA/AA: HR, 0.87; 95% CI, 0.77-0.97; p < 0.01], whereas AA was not associated with prognosis. CONCLUSION: Low omega-6 PUFA levels, particularly DGLA, and a low DGLA/AA ratio predict long-term mortality in patients with acute cardiovascular disease and ADHF. TRIAL REGISTRATION: UMIN-CTR; UMIN000007555 .
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Authors | Shohei Ouchi, Tetsuro Miyazaki, Kazunori Shimada, Yurina Sugita, Megumi Shimizu, Azusa Murata, Takao Kato, Tatsuro Aikawa, Shoko Suda, Tomoyuki Shiozawa, Masaru Hiki, Shuhei Takahashi, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 16
Issue 1
Pg. 150
(Aug 14 2017)
ISSN: 1476-511X [Electronic] England |
PMID | 28806965
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Fatty Acids, Omega-3
- Fatty Acids, Omega-6
- Arachidonic Acid
- 8,11,14-Eicosatrienoic Acid
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Topics |
- 8,11,14-Eicosatrienoic Acid
(blood)
- Acute Coronary Syndrome
(blood, diagnosis, mortality, physiopathology)
- Aged
- Aged, 80 and over
- Analysis of Variance
- Arachidonic Acid
(blood)
- Fatty Acids, Omega-3
(blood)
- Fatty Acids, Omega-6
(blood)
- Female
- Heart Failure
(blood, diagnosis, mortality, physiopathology)
- Humans
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Risk Factors
- Survival Analysis
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