In recent years, it is prevalent to treat various kinds of the
tumors through microwave ablation method. However, it is still very difficult to ablate large
tumors by the traditional microwave ablation
therapy. In this work, an effective microwave embolization agent designed by encapsulating
molybdenum sulfide nanosheets in the
sodium alginate microcapsules, denoted as MSMCs, was prepared for the effective
therapy of large
tumor. The toxicity evaluation showed that MSMC had a good biocompatibility in vitro. The in vitro and in vivo experiments demonstrated that the MSMC was an excellent embolic and microwave susceptible agent that could be used for dual-enhanced microwave ablation
therapy. As such, the MSMC showed excellent
tumor therapeutic effect with 5 times larger ablation zone observed by magnetic resonance (MR) imaging than the microwave alone after 3 days treating. Besides, the
tumor is nearly completely ablated and can not be recurrent due to the persistent
hyperthermia. Moreover, MSMCs have a good biocompatibility and can be degraded and cleared from the body. It is believed that the MSMC is demonstrated to be a promising multifunctional
theranostic agent used for treating the larger
tumor via the synergistic
therapy of enhanced microwave ablation and transcatheter arterial embolization (TAE).