Abstract | BACKGROUND: OBJECTIVE: To evaluate the performance of conventional imaging in detecting cN+ and analyze the impact of cN+ on survival among patients treated with RC without neoadjuvant chemotherapy (NAC). DESIGN, SETTING, AND PARTICIPANTS: Data from three independent centers of consecutive patients with bladder cancer treated with RC without NAC were analyzed. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: cN+ was defined as pelvic nodes >8mm or abdominal nodes >10mm in maximum short-axis diameter as detected via preoperative computed tomography or magnetic resonance imaging. Performance characteristics were evaluated considering pN+ disease as the reference standard. Multivariable Cox regression analyses were performed for prediction of survival. RESULTS AND LIMITATIONS: Overall, 196 patients (7.1%) had cN+ disease before RC and pN+ status was confirmed for 122 of them (62.2%). cN+ status in the overall population had sensitivity of 18% and specificity of 96% with a calculated area under the curve of 57%. The median follow-up was 108 mo. On multivariable analyses, cN+pN+ (hazard ratio [HR] 1.84, 95% confidence interval [CI] 1.26-2.68) and cN-pN+ (HR 2.36, 95% CI 1.90-2.92) were predictors of CSM (both p<0.001). Conversely, cN+pN- status was not associated with worse survival outcomes (p > 0.2). CONCLUSIONS: Our study confirms the poor accuracy of conventional preoperative imaging in assessing nodal disease status. cN status had no independent impact on survival when all confounders were evaluated, and potentially curative treatments should not be withheld on the basis of clinical nodal status alone. PATIENT SUMMARY: The accuracy of conventional imaging techniques for detection of pathologic lymph node-positive disease before radical cystectomy for bladder cancer is suboptimal. The presence of clinical lymph node positivity on preoperative imaging is not an independent predictor of oncologic outcomes, and if the node invasion is not confirmed at radical cystectomy, these patients may have good long-term outcomes.
|
Authors | Marco Moschini, Alessandro Morlacco, Alberto Briganti, Brian Hu, Renzo Colombo, Francesco Montorsi, Igor Frank, Siamak Daneshmand, R Jeffrey Karnes |
Journal | European urology focus
(Eur Urol Focus)
Vol. 4
Issue 2
Pg. 245-251
(03 2018)
ISSN: 2405-4569 [Electronic] Netherlands |
PMID | 28753820
(Publication Type: Journal Article, Multicenter Study, Observational Study)
|
Copyright | Copyright © 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved. |
Topics |
- Aged
- Carcinoma, Transitional Cell
(pathology, surgery)
- Cystectomy
(methods)
- Disease-Free Survival
- Female
- Humans
- Lymph Nodes
(diagnostic imaging, pathology)
- Lymphadenopathy
(etiology)
- Lymphatic Metastasis
(pathology)
- Male
- Middle Aged
- Neoplasm Invasiveness
(pathology)
- Pelvis
(diagnostic imaging, pathology)
- Predictive Value of Tests
- Preoperative Period
- Treatment Outcome
- Urinary Bladder
(pathology)
- Urinary Bladder Neoplasms
(pathology, surgery)
|