Targeted therapies in hematological malignancies using therapeutic monoclonal antibodies against Eph family receptors.

Abstract

The use of monoclonal antibodies (mAbs) and molecules derived from them has achieved considerable attention and success in recent years, establishing this mode of therapy as an important therapeutic strategy in many cancers, in particular hematological tumors. mAbs recognize cell surface antigens expressed on target cells and mediate their function through various mechanisms such as antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity, or immune system modulation. The efficacy of mAb therapy can be improved when they are conjugated to a highly potent payloads, including cytotoxic drugs and radiolabeled isotopes. The Eph family of proteins has received considerable attention in recent years as therapeutic targets for treatment of both solid and hematological cancers. High expression of Eph receptors on cancer cells compared with low expression levels in normal adult tissues makes them an attractive candidate for cancer immunotherapy. In this review, we detail the modes of action of antibody-based therapies with a focus on the Eph family of proteins as potential targets for therapy in hematological malignancies.

• Authors: Sara Charmsaz, Andrew M Scott, Andrew W Boyd
• Journal: Experimental hematology (Exp Hematol) Vol. 54 Pg. 31-39 (10 2017) ISSN: 1873-2399 [Electronic] Netherlands
• PMID: 28751189 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 ISEH – Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Antineoplastic Agents
• Cytotoxins
• Immunoconjugates
• Neoplasm Proteins
• Receptors, Eph Family

Topics

• Antibodies, Monoclonal (biosynthesis, therapeutic use)
• Antibody-Dependent Cell Cytotoxicity (drug effects)
• Antineoplastic Agents (therapeutic use)
• Complement Activation (drug effects)
• Cytotoxins (chemistry, therapeutic use)
• Gene Expression Regulation, Neoplastic
• Hematologic Neoplasms (drug therapy, genetics, immunology, pathology)
• Humans
• Immunoconjugates (chemistry, therapeutic use)
• Immunomodulation (drug effects)
• Immunotherapy (methods)
• Molecular Targeted Therapy
• Neoplasm Proteins (antagonists & inhibitors, genetics, immunology)
• Receptors, Eph Family (antagonists & inhibitors, genetics, immunology)