iRGD-functionalized PEGylated nanoparticles for enhanced colon tumor accumulation and targeted drug delivery.

Abstract

AIM:

To enhance the tumor accumulation and targeted drug delivery for colon cancer therapy, iRGD peptide was introduced to the surface of PEGylated camptothecin-loaded nanoparticles (NPs).

METHODS:

Cellular uptake, targeting specificity, biodistribution and antitumor capacity were evaluated.

RESULTS:

The functionalization of iRGD facilitated tumor accumulation and cellular uptake of NPs by Colon-26 cells. Furthermore, the resultant iRGD-PEG-NPs remarkably improved the therapeutic efficacy of camptothecin in vitro and in vivo by inducing a higher degree of tumor cell apoptosis compared with PEG-NPs.

CONCLUSION:

iRGD-PEG-NP is a desired drug delivery system to facilitate the drug accumulation in orthotopic colon tumor tissues and further drug internalization by colon cancer cells.

• Authors: Lijun Ma, Qiubing Chen, Panpan Ma, Moon Kwon Han, Zhigang Xu, Yuejun Kang, Bo Xiao, Didier Merlin
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 12 Issue 16 Pg. 1991-2006 (Aug 2017) ISSN: 1748-6963 [Electronic] England
• PMID: 28745123 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Drug Carriers
• N-end cysteine peptide tumor-homing peptide
• Oligopeptides
• Polyglycolic Acid
• Camptothecin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, pharmacology, therapeutic use)
• Apoptosis (drug effects)
• Camptothecin (administration & dosage, chemistry, pharmacology, therapeutic use)
• Cell Line, Tumor
• Colonic Neoplasms (drug therapy)
• Drug Carriers (chemistry)
• Drug Liberation
• Female
• Humans
• Mice
• Nanoparticles (chemistry)
• Oligopeptides (chemistry)
• Particle Size
• Polyglycolic Acid (chemistry)
• Surface Properties
• Tissue Distribution