Abstract | AIM: PATIENTS AND METHODS: Fifty consecutive patients with cStage IIB-IV TESCC were enrolled. We analyzed the pathological response and metabolic response (fractional decrease in tumor maximum standardized uptake value) to NACRT. Independent prognostic factors predictive of 3-year survival were investigated using univariate and multivariate analyses. RESULTS: Among the 50 patients, 10 (20%) showed a pathological complete response (in both tumor and lymph nodes) and 36 (72%) showed grade 2-3 pathological response. Univariate analysis showed that age, gender, cT stage, pathological response and metabolic response to be significant prognostic factors. A subsequent multivariate analysis confirmed metabolic response and gender to be significant prognostic factors. CONCLUSION: Metabolic response for NACRT was an independent prognostic factor and a more powerful predictor of survival compared to pathological response.
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Authors | Satoru Motoyama, Yusuke Sato, Kiyotomi Maruyama, Shuetsu Usami, Kei Yoshino, Toshinobu Nakatsu, Tomohiko Sasaki, Akiyuki Wakita, Yuta Kawakita, Jiajia Liu, Akira Anbai, Kouichi Ishiyama, Hajime Saito, Yoshihiro Minamiya |
Journal | Anticancer research
(Anticancer Res)
Vol. 37
Issue 8
Pg. 4189-4194
(08 2017)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 28739705
(Publication Type: Journal Article)
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Copyright | Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Topics |
- Aged
- Carcinoma, Squamous Cell
(drug therapy, metabolism, pathology, surgery)
- Disease-Free Survival
- Esophageal Neoplasms
(drug therapy, metabolism, pathology, surgery)
- Esophageal Squamous Cell Carcinoma
- Esophagectomy
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoadjuvant Therapy
(methods)
- Neoplasm Staging
- Preoperative Care
- Treatment Outcome
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