Abstract | BACKGROUND/AIMS: METHODS: The study comprised 25 CF patients with liver cirrhosis and 25 without it. We assessed Z-scores for body height and weight, lung function, exocrine pancreatic sufficiency and colonization with Pseudomonas aeruginosa. FAs' profile of serum glycerophospholipids was quantified by gas chromatography mass spectrometry. RESULTS: In CF patients with liver cirrhosis, the levels of C16:0 were higher and the amounts of C20:2n-6, C20:3n-6, C20:4n-6, and all the n-3 polyunsaturated FAs (PUFAs) (C18:3n-3, C20:5n-3, C22:5n-3, C22:6n-3) were lower than those in CF subjects without liver cirrhosis. The n-6/n-3, C20:4n-6/C18:2n-6, total n-6/C18:2n-6, C20:5n-3/C18:3n-3 and total n-3/C18:3n-3 ratios did not differ between the 2 groups. CONCLUSIONS:
Liver cirrhosis may associate with profound abnormalities in the composition of serum glycerophospholipids FAs in CF patients. None of the analyzed clinical factors could explain the greater prevalence of low levels of PUFAs in this CF subgroup.
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Authors | Sławomira Drzymała-Czyż, Mariusz Szczepanik, Patrycja Krzyżanowska, Monika Duś-Żuchowska, Andrzej Pogorzelski, Ewa Sapiejka, Paweł Juszczak, Aleksandra Lisowska, Berthold Koletzko, Jarosław Walkowiak |
Journal | Annals of nutrition & metabolism
(Ann Nutr Metab)
Vol. 71
Issue 1-2
Pg. 91-98
( 2017)
ISSN: 1421-9697 [Electronic] Switzerland |
PMID | 28738321
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2017 S. Karger AG, Basel. |
Chemical References |
- Dietary Carbohydrates
- Dietary Fats
- Dietary Proteins
- Fatty Acids
- Fatty Acids, Unsaturated
- Glycerophospholipids
- Phospholipids
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Topics |
- Adolescent
- Adult
- Anthropometry
- Child
- Cystic Fibrosis
(blood)
- Diet
- Dietary Carbohydrates
(administration & dosage)
- Dietary Fats
(administration & dosage)
- Dietary Proteins
(administration & dosage)
- Fatty Acids
(administration & dosage, blood)
- Fatty Acids, Unsaturated
(administration & dosage, blood)
- Female
- Glycerophospholipids
(blood)
- Humans
- Lipid Metabolism
- Liver Cirrhosis
(blood)
- Male
- Phospholipids
(administration & dosage, blood)
- Young Adult
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