Abstract | BACKGROUND/OBJECTIVES: SUBJECTS/METHODS: The subjects were 82 044 Japanese men and women aged 45-74 years under the Japan Public Health Center-based Prospective Cohort Study. Between 1995 and 1997, dietary assessment was done using a food frequency questionnaire. During 983 857 person-years of follow-up until the end of 2009 we documented 3541 incident total strokes and 2138 ischemic strokes. RESULTS: Dietary intakes of α- carotene, β- carotene, α- tocopherol and vitamin C were not inversely associated with the incidence of total stroke and ischemic stroke adjustment for cardiovascular risk factors and selected lifestyle variables. When stratified by current smoking status, the inverse association between dietary vitamin C intake and incidence of total stroke observed among non-smokers but not smokers, with respective multivariable hazard ratios for the highest versus lowest quintiles of vitamin C of 0.81 (95% confidence interval (CI), 0.68-0.96; P-trend=0.03) among non-smokers; and 1.03 (0.84-1.25; P-trend=0.55) among smokers. As for ischemic stroke, the corresponding multivariable hazard ratios were 0.76 (0.60-0.96; P-trend=0.02) among non-smokers; and 1.00 (0.78-1.28; P-trend=0.61) among smokers. CONCLUSIONS:
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Authors | S Uesugi, J Ishihara, H Iso, N Sawada, R Takachi, M Inoue, S Tsugane |
Journal | European journal of clinical nutrition
(Eur J Clin Nutr)
Vol. 71
Issue 10
Pg. 1179-1185
(10 2017)
ISSN: 1476-5640 [Electronic] England |
PMID | 28699629
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Ascorbic Acid
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Topics |
- Aged
- Antioxidants
(administration & dosage)
- Ascorbic Acid
(administration & dosage)
- Cohort Studies
- Dietary Supplements
- Female
- Health Services for the Aged
- Humans
- Incidence
- Japan
(epidemiology)
- Male
- Middle Aged
- Nutrition Surveys
- Prospective Studies
- Risk Factors
- Stroke
(epidemiology, etiology, prevention & control)
- Surveys and Questionnaires
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