New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells.

Abstract

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

• Authors: Parikshit Moitra, Krishan Kumar, Sourav Sarkar, Paturu Kondaiah, Wei Duan, Santanu Bhattacharya
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 53 Issue 58 Pg. 8184-8187 (Jul 18 2017) ISSN: 1364-548X [Electronic] England
• PMID: 28678285 (Publication Type: Journal Article)

Chemical References

• 1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3)
• Antineoplastic Agents
• Drug Carriers
• Lipids
• Liposomes
• Doxorubicin
• Calcitriol

Topics

• Antineoplastic Agents (administration & dosage, chemistry, pharmacology)
• Calcitriol (analogs & derivatives, chemistry)
• Cell Survival (drug effects)
• Dose-Response Relationship, Drug
• Doxorubicin (administration & dosage, chemistry, pharmacology)
• Drug Carriers (chemistry)
• Drug Resistance, Neoplasm (drug effects)
• Drug Screening Assays, Antitumor
• HeLa Cells
• Humans
• Hydrogen-Ion Concentration
• Lipids (chemistry)
• Liposomes
• Molecular Structure
• Structure-Activity Relationship