Laparoscopic versus open distal pancreatectomy for pancreatic ductal adenocarcinoma: a single-center experience.

Abstract

OBJECTIVE:

The aim of this study was to compare complications and oncologic outcomes of patients undergoing laparoscopic distal pancreatectomy (LDP) and open distal pancreatectomy (ODP) at a single center.

METHODS:

Distal pancreatectomies performed for pancreatic ductal adenocarcinoma during a 4-year period were included in this study. A retrospective analysis of a database of this cohort was conducted.

RESULTS:

Twenty-two patients underwent LDP for pancreatic ductal adenocarcinoma, in comparison to seventy-six patients with comparable tumor characteristics treated by ODP. No patients with locally advanced lesions were included in this study. Comparing LDP group to ODP group, there were no significant differences in operation time (P=0.06) or blood loss (P=0.24). Complications (pancreatic fistula, P=0.62; intra-abdominal abscess, P=0.44; postpancreatectomy hemorrhage, P=0.34) were similar. There were no significant differences in the number of lymph nodes harvested (11.2±4.6 in LDP group vs. 14.4±5.5 in ODP group, P=0.44) nor the rate of patients with positive lymph nodes (36% in LDP group vs. 41% in ODP group, P=0.71). Incidence of positive margins was similar (9% in LDP group vs. 13% in ODP group, P=0.61). The mean overall survival time was (29.6±3.7) months for the LDP group and (27.6±2.1) months for ODP group. There was no difference in overall survival between the two groups (P=0.34).

CONCLUSIONS:

LDP is a safe and effective treatment for selected patients with pancreatic ductal adenocarcinoma. A slow-compression of pancreas tissue with the GIA stapler is effective in preventing postoperative pancreatic fistula. The oncologic outcome is comparable with the conventional open approach. Laparoscopic radical antegrade modular pancreatosplenectomy contributed to oncological clearance.

• Authors: Ai-Bin Zhang, Ye Wang, Chen Hu, Yan Shen, Shu-Sen Zheng
• Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) Vol. 18 Issue 6 Pg. 532-538 (Jun 2017) ISSN: 1862-1783 [Electronic] China
• PMID: 28585429 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• Blood Loss, Surgical
• Carcinoma, Pancreatic Ductal (surgery)
• Female
• Humans
• Kaplan-Meier Estimate
• Laparoscopy (adverse effects, methods)
• Male
• Middle Aged
• Operative Time
• Pancreatectomy (adverse effects, methods)
• Pancreatic Fistula (prevention & control)
• Pancreatic Neoplasms (surgery)
• Postoperative Complications (prevention & control)
• Retrospective Studies
• Pancreatic Neoplasms