Review on the Biological Mechanisms Associated with Depo-Provera and HIV-1 Risk Acquisition in Women.

Abstract

Women constitute more than 50% out of millions of individuals infected with HIV-1, the major causative agent of acquired immune deficiency syndrome. About 40% of HIV-1 infections have been reported to initiate in the female reproductive tract. However, the mechanisms through which these infections are spread are poorly understood; hence, there is now a major concern in women who use long acting injectable hormonal contraceptives, particularly Depo-Provera and an increase of HIV-1 risk acquisition. Based on literature, Depo-Provera has an affinity for both the glucocorticoid receptor and the progesterone receptor in the female reproductive tract. Therefore, investigating HIV-1 pathogenesis in the female reproductive tract via the glucocorticoid receptor and the progesterone receptor mechanisms in response to the effect of Depo-Provera is of great importance.

• Authors: Funanani Takalani, Ndumiso N Mhlongo, Suri Moonsamy, Mahmoud E S Soliman
• Journal: Cell biochemistry and biophysics (Cell Biochem Biophys) Vol. 76 Issue 1-2 Pg. 73-82 (Jun 2018) ISSN: 1559-0283 [Electronic] United States
• PMID: 28577243 (Publication Type: Journal Article, Review)

Chemical References

• Aniline Compounds
• Anti-Retroviral Agents
• NF-kappa B
• Receptors, Glucocorticoid
• Receptors, Progesterone
• N,N-dimethyl-4-anisidine
• Medroxyprogesterone Acetate

Topics

• Aniline Compounds (metabolism)
• Anti-Retroviral Agents (therapeutic use)
• Female
• Genitalia, Female (metabolism)
• HIV Infections (drug therapy, etiology, virology)
• HIV-1 (physiology)
• Humans
• Medroxyprogesterone Acetate (metabolism)
• NF-kappa B (metabolism)
• Receptors, Glucocorticoid (metabolism)
• Receptors, Progesterone (metabolism)
• Risk Factors