Abstract | BACKGROUND & OBJECTIVES: METHODS: In this study, 75 male Sprague-Dawley rats were divided into five groups. Oral squamous cell carcinoma (OSCC) was induced by using 4- nitroquinoline-1-oxide (4NQO) as a carcinogen. Newly formulated doxorubicin (DOX)- methotrexate (MTX)-loaded nanoparticles, and free DOX-MTX were administrated intravenously to rats. During the study, the animals were weighed once a week. At the end of the treatment, rats' tongues were evaluated histopathologically. RESULTS: There was significant difference between the mean weight of rats in groups A and B (P=0.001) and also groups A and K (P<0.001). No significant association was found between the mortality rate of groups. The difference between the severity of dysplasia of treated and untreated groups was significant (P<0.001). INTERPRETATION & CONCLUSIONS: Our study showed that DOX-MTX nanoparticle complex was more effective than free DOX-MTX in chemotherapy treatment of oral squamous cell carcinoma in rat models. Further investigations are necessary to clarify the advantages and disadvantages of the nanoparticle complex and its potential therapeutic application for different types of cancer.
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Authors | Monir Moradzadeh Khiavi, Khadijeh Abdal, Mehran Mesgari Abbasi, Hamed Hamishehkar, Amir Ala Aghbali, Roya Salehi, Mahmoud Sina, Bita Abdollahi, Soheila Fotohi |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 145
Issue 1
Pg. 112-117
(Jan 2017)
ISSN: 0971-5916 [Print] India |
PMID | 28574023
(Publication Type: Journal Article)
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Chemical References |
- 4-Nitroquinoline-1-oxide
- Doxorubicin
- Methotrexate
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Topics |
- 4-Nitroquinoline-1-oxide
(toxicity)
- Animals
- Carcinoma, Squamous Cell
(chemically induced, drug therapy, pathology)
- Disease Models, Animal
- Doxorubicin
(administration & dosage, chemistry)
- Drug Delivery Systems
- Head and Neck Neoplasms
(chemically induced, drug therapy, pathology)
- Humans
- Methotrexate
(administration & dosage, chemistry)
- Nanoparticles
(administration & dosage, chemistry)
- Rats
- Squamous Cell Carcinoma of Head and Neck
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