Approach to growth hormone therapy in children with chronic kidney disease varies across North America: the Midwest Pediatric Nephrology Consortium report.

Abstract

BACKGROUND:

Growth impairment remains common in children with chronic kidney disease (CKD). Available literature indicates low level of recombinant human growth hormone (rhGH) utilization in short children with CKD. Despite efforts at consensus guidelines, lack of high-level evidence continues to complicate rhGH therapy decision-making and the level of practice variability in rhGH treatment by pediatric nephrologists is unknown.

METHODS:

Cross-sectional online survey electronically distributed to pediatric nephrologists through the Midwest Pediatric Nephrology Consortium and American Society of Pediatric Nephrology.

RESULTS:

Seventy three pediatric nephrologists completed the survey. While the majority (52.1%) rarely involve endocrinology in rhGH management, 26.8% reported that endocrinology managed most aspects of rhGH treatment in their centers. The majority of centers (68.5%) have a dedicated renal dietitian, but 20.6% reported the nephrologist as the primary source of nutritional support for children with CKD. Children with growth failure did not receive rhGH most commonly because of family refusal. Differences in initial work-up for rhGH therapy include variable use of bone age (95%), thyroid function (58%), insulin-like growth factor-1 (40%), hip/knee X-ray (36%), and ophthalmologic evaluation (7%). Most pediatric nephrologists (95%) believe that rhGH treatment improves quality of life, but only 24% believe that it improves physical function; 44% indicated that rhGH improves lean body mass.

CONCLUSIONS:

There is substantial variation in pediatric nephrology practice in addressing short stature and rhGH utilization in children with CKD. Hence, there may be opportunities to standardize care to study and improve growth outcomes in short children with CKD.

• Authors: Oleh M Akchurin, Amy J Kogon, Juhi Kumar, Christine B Sethna, Hoda T Hammad, Paul J Christos, John D Mahan, Larry A Greenbaum, Robert Woroniecki
• Journal: BMC nephrology (BMC Nephrol) Vol. 18 Issue 1 Pg. 181 (May 30 2017) ISSN: 1471-2369 [Electronic] England
• PMID: 28558814 (Publication Type: Journal Article)

Chemical References

• IGF1 protein, human
• Recombinant Proteins
• Human Growth Hormone
• Insulin-Like Growth Factor I

Topics

• Age Determination by Skeleton
• Attitude of Health Personnel
• Child
• Cross-Sectional Studies
• Endocrinology
• Growth Disorders (diagnosis, drug therapy, etiology)
• Hip (diagnostic imaging)
• Human Growth Hormone (therapeutic use)
• Humans
• Insulin-Like Growth Factor I (metabolism)
• Knee (diagnostic imaging)
• Nephrology
• North America
• Patient Care Team
• Pediatrics
• Practice Patterns, Physicians'
• Recombinant Proteins (therapeutic use)
• Renal Insufficiency, Chronic (complications)
• Surveys and Questionnaires
• Thyroid Function Tests