Abstract | BACKGROUND: A broad range of metal-coordinated complexes have been studied for their anticancer activities. However, some of these complexes display high toxicity profiles to non-malignant cells, therefore limiting their use in cancer therapeutics. Aims/Method: Several silver(I) triphenylphosphine adducts were prepared as 1:1 to 1:4 ratios of silver nitrate to triphenylphosphine. They were further used to determine their anticancer activity in a malignant SNO esophageal cell line. The silver(I) phosphine adducts include: [Ag(PPh3)]NO3 (1); [Ag(PPh3)2]NO3 (2); [Ag(PPh3)3]NO3 (3) and [Ag(PPh3)4]NO3 (4). In addition, the activity of complexes 1-4 was compared to previously reported complexes [Ag(Ph2P(CH2)2PPh2)2]NO3 (5) and [Ag(Ph2P(CH2)3PPh2)2]NO3 (6). The cytotoxicity of complexes 1-6 was also evaluated in non-malignant human dermal fibroblast cells (HDF-a). RESULTS: The majority of the complexes (specifically those containing PPh3) were found to be highly toxic to the SNO cells and less toxic towards HDF-a cells, as determined by the alamarBlue® assay. Morphological studies and flow cytometry confirmed that the silver(I) complexes induced apoptosis in the malignant cells. CONCLUSION: These results may have an impact on research related to drug discovery and silver(I) phosphine complexes could be added to the arsenal of anticancer agents in addition to the silver-bis-diphenylphosphinoethane and silver-bis-diphenylphosphinopropane adducts.
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Authors | Zelinda Engelbrecht, Kariska Potgieter, Zanele Mpela, Rehana Malgas-Enus, Reinout Meijboom, Marianne J Cronje |
Journal | Anti-cancer agents in medicinal chemistry
(Anticancer Agents Med Chem)
Vol. 18
Issue 3
Pg. 394-400
( 2018)
ISSN: 1875-5992 [Electronic] Netherlands |
PMID | 28530542
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright© Bentham Science Publishers; For any queries, please email at [email protected]. |
Chemical References |
- Coordination Complexes
- Phosphines
- Silver
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Topics |
- Cell Death
(drug effects)
- Cell Proliferation
(drug effects)
- Cell Survival
(drug effects)
- Coordination Complexes
(chemical synthesis, chemistry, pharmacology)
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Esophageal Neoplasms
(drug therapy, pathology)
- Humans
- Molecular Structure
- Phosphines
(chemistry, pharmacology)
- Silver
(chemistry, pharmacology)
- Structure-Activity Relationship
- Tumor Cells, Cultured
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