Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy.
|
| Abstract |
Valproic acid (VPA) is widely used for the treatment of epilepsy. However, its overdose can cause intoxication and could be life-threatening. Due to the lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of VPA which was successfully treated with liver support therapy. A previously healthy woman was admitted due to coma and hypotension after intentional ingestion of 20 g of sodium valproate. Her serum concentration of VPA measured on admission was 420.84 mg/L. In addition to standard therapy, she received two sessions of extracorporeal blood purification using a system based on fractionated plasma separation and adsorption mode integrated with continuous veno-venous haemofiltration (FPSA-CVVH), which is usually used for liver support therapy at our hospital. Her serum concentration of VPA decreased dramatically to 40.18 mg/L and her consciousness recovered completely within 24 hr after admission. Therefore, although haemodialysis has been reported to be effective in the treatment for VPA poisoning, FPSA-CVVH may provide an option for patients who require bedside therapy but have an unstable haemodynamic status or other conditions that result in inability to endure haemodialysis.
|
|---|---|
| Authors | Yongchun Ge, Bin Xu, Shuhua Zhu, Chuan Li, Qunpeng He, Tingting Zhu, Rong Fan, Dehua Gong |
| Journal | Basic & clinical pharmacology & toxicology (Basic Clin Pharmacol Toxicol) Vol. 121 Issue 4 Pg. 368-370 (Oct 2017) ISSN: 1742-7843 [Electronic] England |
| PMID | 28481454 (Publication Type: Case Reports) |
| Copyright | © 2017 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!