Advanced Analgesic Drug Delivery and Nanobiotechnology.

Abstract

Transdermal administration of analgesic medications offers several benefits over alternative routes of administration, including a decreased systemic drug load with fewer side effects, and avoidance of drug degradation by the gastrointestinal tract. Transdermal administration also offers a convenient mode of drug administration over an extended period of time, particularly desirable in pain medicine. A transdermal administration route may also offer increased safety for drugs with a narrow therapeutic window. The primary barrier to transdermal drug absorption is the skin itself. Transdermal nanotechnology offers a novel method of achieving enhanced dermal penetration with an extended delivery profile for analgesic drugs, due to their small size and relatively large surface area. Several materials have been used to enhance drug duration and transdermal penetration. The application of nanotechnology in transdermal delivery of analgesics has raised new questions regarding safety and ethical issues. The small molecular size of nanoparticles enables drug delivery to previously inaccessible body sites. To ensure safety, the interaction of nanoparticles with the human body requires further investigation on an individual drug basis, since different formulations have unique properties and side effects.

• Authors: Nicoleta Stoicea, Juan Fiorda-Diaz, Nicholas Joseph, Muhammad Shabsigh, Carlos Arias-Morales, Alicia A Gonzalez-Zacarias, Ana Mavarez-Martinez, Stephen Marjoribanks, Sergio D Bergese
• Journal: Drugs (Drugs) Vol. 77 Issue 10 Pg. 1069-1076 (Jul 2017) ISSN: 1179-1950 [Electronic] New Zealand
• PMID: 28470586 (Publication Type: Journal Article, Review)

Chemical References

• Analgesics

Topics

• Administration, Cutaneous
• Analgesics (administration & dosage, adverse effects, pharmacokinetics)
• Animals
• Drug Delivery Systems
• Drug Liberation
• Humans
• Nanoparticles (chemistry)
• Nanotechnology
• Skin Absorption