Abstract | OBJECTIVE: DATA SOURCES: PubMed, EMBASE, Cochrane library, Web of Science, and bibliographies of articles were retrieved inception until June 2016. STUDY SELECTION: DATA EXTRACTION: Demographic variables, noninvasive ventilation application, and outcomes were retrieved. Internal validity was assessed using the risk of bias tool. The strength of evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation methodology. DATA SYNTHESIS: Eleven studies (1,480 patients) met the inclusion criteria and were analyzed by using a random effects model. Compared with standard oxygen therapy, the pooled effect showed that noninvasive ventilation significantly reduced intubation rate with a summary risk ratio of 0.59 (95% CI, 0.44-0.79; p = 0.0004). Furthermore, hospital mortality was also significantly reduced (risk ratio, 0.46; 95% CI, 0.24-0.87; p = 0.02). Subgroup meta-analysis showed that the application of bilevel positive support ventilation ( bilevel positive airway pressure) was associated with a reduction in ICU mortality (p = 0.007). Helmet noninvasive ventilation could reduce hospital mortality (p = 0.0004), whereas face/nasal mask noninvasive ventilation could not. CONCLUSIONS:
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Authors | Xiu-Ping Xu, Xin-Chang Zhang, Shu-Ling Hu, Jing-Yuan Xu, Jian-Feng Xie, Song-Qiao Liu, Ling Liu, Ying-Zi Huang, Feng-Mei Guo, Yi Yang, Hai-Bo Qiu |
Journal | Critical care medicine
(Crit Care Med)
Vol. 45
Issue 7
Pg. e727-e733
(Jul 2017)
ISSN: 1530-0293 [Electronic] United States |
PMID | 28441237
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Topics |
- Acute Disease
- Adult
- Aged
- Female
- Hospital Mortality
- Humans
- Intubation, Intratracheal
(statistics & numerical data)
- Male
- Middle Aged
- Noninvasive Ventilation
(methods)
- Randomized Controlled Trials as Topic
- Respiratory Insufficiency
(therapy)
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