Learning and memory processes of an ACTH4-9 analog (ebiratide; Hoe 427) in mice and rats.

Abstract

These experiments investigated the effects of the new ACTH4-9 analog ebiratide (Hoe 427) [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH-(CH2)8-NH2 X 3 CH3COOH] on memory processes in mice and rats in five training tasks. With all five training and testing procedures (inhibitory avoidance test with ECS- or scopolamine-induced amnesia, up-hill avoidance, one-way shuttle box avoidance and eight-arm radial maze) ebiratide was most effective in a dose range of 1-10 micrograms/kg SC.

• Authors: F J Hock, H J Gerhards, G Wiemer, P Usinger, R Geiger
• Journal: Peptides (Peptides) 1988 May-Jun Vol. 9 Issue 3 Pg. 575-81 ISSN: 0196-9781 [Print] United States
• PMID: 2843833 (Publication Type: Journal Article)

Chemical References

• Peptide Fragments
• Adrenocorticotropic Hormone
• ebiratide
• Scopolamine

Topics

• Adrenocorticotropic Hormone (analogs & derivatives, pharmacology)
• Animals
• Avoidance Learning (drug effects)
• Electroshock
• Male
• Memory (drug effects)
• Mice
• Mice, Inbred Strains
• Peptide Fragments (pharmacology)
• Reference Values
• Scopolamine (pharmacology)
• Social Isolation