The prognostic value of B7-H6 protein expression in human oral squamous cell carcinoma.

Abstract

OBJECTIVES:

To investigate the expression and prognostic value of B7-H6 protein in oral squamous cell carcinoma tissues.

MATERIALS AND METHODS:

A total of 50 oral squamous cell carcinoma samples, 10 oral leukoplakia (OLK) samples, and 17 normal controls were included in the analysis. The expression of B7-H6 in oral squamous cell carcinoma, OLK, and normal controls was evaluated by immunohistochemical assay.

RESULTS:

The B7-H6 protein expression was significantly higher in oral squamous cell carcinoma tissues than that in normal oral mucosa. Furthermore, a significant relationship was found between the expression of B7-H6 and differentiation, but not with age, sex, tumor size, lymph metastasis, clinical stage, or recurrence. Further, the survival curves showed that B7-H6 was an independent prognostic factor of overall survival and disease-free survival in oral squamous cell carcinoma. Moreover, multivariate survival analysis by COX proportional hazard regression model revealed that the recurrence, differentiation, and expression of B7-H6 were related to the prognosis. Lastly, we verified the prognostic value of B7-H6 in oral squamous cell carcinoma.

CONCLUSIONS:

B7-H6 may represent a new prognostic marker for oral squamous cell carcinoma.

• Authors: Jiongke Wang, Xin Jin, Jiajia Liu, Kui Zhao, Hao Xu, Jing Wen, Lu Jiang, Xin Zeng, Jing Li, Qianming Chen
• Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 46 Issue 9 Pg. 766-772 (Oct 2017) ISSN: 1600-0714 [Electronic] Denmark
• PMID: 28437013 (Publication Type: Journal Article)
• Copyright: © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• B7 Antigens
• NCR3LG1 protein, human

Topics

• Adult
• Aged
• Aged, 80 and over
• B7 Antigens (biosynthesis)
• Carcinoma, Squamous Cell (metabolism, mortality)
• Female
• Humans
• Male
• Middle Aged
• Mouth Neoplasms (metabolism, mortality)
• Prognosis
• Survival Rate