Abstract |
Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelength lies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonant wavelength at near-infrared region - the area where the source of light utilized by optical coherence tomography (OCT) lies. With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm. The synthesized nanoparticles were successfully visualized in in vivo OCT at concentrations as low as 1 pM. After demonstrating their binding ability to vascular endothelial growth factor ( VEGF), we show that they suppress VEGF-induced migration of endothelial cells. Finally, we demonstrate that intravitreally injected gold nanodisks attenuate neovascularization of oxygen-induced retinopathy in mice, in a dose dependent manner, such that they are cleared from the vitreous within 2 weeks without histologic or electrophysiologic toxicity.
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Authors | Hyun Beom Song, Jung-Sub Wi, Dong Hyun Jo, Jin Hyoung Kim, Sang-Won Lee, Tae Geol Lee, Jeong Hun Kim |
Journal | Nanomedicine : nanotechnology, biology, and medicine
(Nanomedicine)
Vol. 13
Issue 6
Pg. 1901-1911
(Aug 2017)
ISSN: 1549-9642 [Electronic] United States |
PMID | 28400160
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Angiogenesis Inhibitors
- Vascular Endothelial Growth Factors
- Gold
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Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Animals
- Cell Survival
(drug effects)
- Gold
(therapeutic use)
- Injections, Intraocular
- Metal Nanoparticles
(chemistry, therapeutic use)
- Mice
- Mice, Inbred C57BL
- Retinal Diseases
(drug therapy, metabolism, pathology)
- Retinal Neovascularization
(drug therapy, metabolism, pathology)
- Tomography, Optical Coherence
(instrumentation, methods)
- Vascular Endothelial Growth Factors
(metabolism)
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