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Intraocular application of gold nanodisks optically tuned for optical coherence tomography: inhibitory effect on retinal neovascularization without unbearable toxicity.

Abstract
Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelength lies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonant wavelength at near-infrared region - the area where the source of light utilized by optical coherence tomography (OCT) lies. With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm. The synthesized nanoparticles were successfully visualized in in vivo OCT at concentrations as low as 1 pM. After demonstrating their binding ability to vascular endothelial growth factor (VEGF), we show that they suppress VEGF-induced migration of endothelial cells. Finally, we demonstrate that intravitreally injected gold nanodisks attenuate neovascularization of oxygen-induced retinopathy in mice, in a dose dependent manner, such that they are cleared from the vitreous within 2 weeks without histologic or electrophysiologic toxicity.
AuthorsHyun Beom Song, Jung-Sub Wi, Dong Hyun Jo, Jin Hyoung Kim, Sang-Won Lee, Tae Geol Lee, Jeong Hun Kim
JournalNanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 13 Issue 6 Pg. 1901-1911 (Aug 2017) ISSN: 1549-9642 [Electronic] United States
PMID28400160 (Publication Type: Journal Article)
CopyrightCopyright © 2017 Elsevier Inc. All rights reserved.
Chemical References
  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factors
  • Gold
Topics
  • Angiogenesis Inhibitors (therapeutic use)
  • Animals
  • Cell Survival (drug effects)
  • Gold (therapeutic use)
  • Injections, Intraocular
  • Metal Nanoparticles (chemistry, therapeutic use)
  • Mice
  • Mice, Inbred C57BL
  • Retinal Diseases (drug therapy, metabolism, pathology)
  • Retinal Neovascularization (drug therapy, metabolism, pathology)
  • Tomography, Optical Coherence (instrumentation, methods)
  • Vascular Endothelial Growth Factors (metabolism)

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