Recent Advances in Oncological Submissions of Dendrimer.

Abstract

BACKGROUND:

Disseminated metastatic cancer requires insistent management owing to its reduced responsiveness for chemotherapeutic agents, toxicity to normal cells consequently lower survival rate and hampered quality of life of patients.

METHODS:

Dendrimer mediated cancer therapy is advantageous over conventional chemotherapy, radiotherapy and surgical resection due to reduced systemic toxicity, and molecular level cell injury to cancerous mass, for an appreciable survival of the subject. Recently used dendrimer mediated nanotechnology for oncology aims to conquer these challenges. Dendrimers based nano-constructs are having architectures comparable to that of biological vesicles present in the human body.

RESULTS:

Operating with dendrimer technology, proffers the exclusive and novel strategies with numerous applications in cancer management involving diagnostics, therapeutics, imaging, and prognostics by sub-molecular interactions. Dendrimers are designed to acquire the benefits of the malignant tumor morphology and characteristics, i.e. leaky vasculature of tumor, expression of specific cell surface antigen, and rapid proliferation.

CONCLUSION:

Dendrimers mediated targeted therapy recommends innovatory function equally in diagnostics (imaging, immune-detection) as well as chemotherapy. Currently, dendrimers as nanomedicine has offered a strong assurance and advancement in drastically varying approaches towards cancer imaging and treatment. The present review discusses different approaches for cancer diagnosis and treatment such as, targeted and control therapy, photodynamic therapy, photo-thermal therapy, gene therapy, antiangiogenics therapy, radiotherapy etc.

• Authors: Namrata Soni, Muktika Tekade, Prashant Kesharwani, Pallab Bhattacharya, Rahul Maheshwari, Kamal Dua, Philp M Hansbro, Rakesh Kumar Tekade
• Journal: Current pharmaceutical design (Curr Pharm Des) Vol. 23 Issue 21 Pg. 3084-3098 (08 30 2017) ISSN: 1873-4286 [Electronic] United Arab Emirates
• PMID: 28356042 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Dendrimers

Topics

• Dendrimers (administration & dosage, chemical synthesis, chemistry, therapeutic use)
• Humans
• Neoplasm Metastasis
• Neoplasms (drug therapy, pathology)