Dendrimers (Dendrons)

Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.

Also Known As:

Networked: 1702 relevant articles (139 outcomes, 260 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shi, Xiangyang: 96 articles (11/2022 - 07/2005)
2.	Kannan, Rangaramanujam M: 51 articles (01/2022 - 01/2004)
3.	Shen, Mingwu: 49 articles (02/2022 - 07/2009)
4.	Baker, James R: 45 articles (09/2020 - 09/2002)
5.	Bryszewska, Maria: 43 articles (07/2022 - 01/2006)
6.	Kannan, Sujatha: 40 articles (01/2022 - 01/2004)
7.	Majoral, Jean-Pierre: 36 articles (11/2022 - 06/2004)
8.	Caminade, Anne-Marie: 30 articles (11/2022 - 06/2004)
9.	Gómez, Rafael: 30 articles (02/2022 - 11/2008)
10.	Kesharwani, Prashant: 26 articles (01/2022 - 06/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "Cancer nanotherapeutics have shown promise in resolving some of the limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, and low therapeutic indices, Among the various nanoparticles that are available, dendrimers, highly branched macromolecules with a specific size and shape, are one of the most promising ones. " 12/28/2013 - "This review analyzes these techniques applied to liposomal, PEI, dendrimer, stem cell and viral gene delivery systems in order to determine the techniques that are most effective in achieving tumor specific gene expression after systemic administration. " 04/04/2011 - "In contrast the equivalent dendrimer comprising uncapped MTX conjugated to the dendrimer via the same hexapeptide linker did not reduce tumor growth, presumably reflecting very rapid clearance of the construct. " 11/05/2013 - "A significantly enhanced oncolytic effect was observed following systemic application of dendrimer-coated adenovirus that was further increased by additional treatment with a therapeutic dose of (131)I. These results demonstrate restricted virus tropism and tumor-selective retargeting after systemic application of coated, EGFR-targeted adenoviruses therefore representing a promising strategy for improved systemic adenoviral NIS gene therapy.Molecular" 04/21/2010 - "These results also imply that Gd(III) dendrimeric hybridization probes might be suitable for magnetic resonance imaging of gene expression in tumors, because the higher generations of the dendrimers, including the NMR contrast Gd(n)-KRAS2 G12 V probes, improved tumor accumulation of the probes and specificity of tumor imaging."
2.	Breast Neoplasms (Breast Cancer) 10/01/2017 - "In the present study, the efficacy of CXCR4 targeted dendrimers carrying DOX (LFC131-DOX-D4) on cellular binding, cytotoxicity, and migration of BT-549-Luc and T47D breast cancer cells was investigated. " 06/13/2016 - "In vitro and in vivo uptake studies of PAMAM G4.5 dendrimers in breast cancer." 04/07/2016 - "Comparative in vitro studies revealed that these targeted dendrimers were more selective, and had higher antiproliferation activity, towards HER2-positive MDA-MB-453 human breast cancer cells than HER2-negative MDA-MB-231 human breast cancer cells. " 01/01/2023 - "Core-shell tecto dendrimer-mediated cooperative chemoimmunotherapy of breast cancer." 12/01/2022 - "In this review, we have highlighted the application of dendrimer as novel multifunctional nanoplatforms for the treatment and diagnosis of Breast Cancer."
3.	Infections 06/28/2020 - "We present the main achievements obtained for the G2-S16 dendrimer in vivo, especially related to its efficacy against HSV-2 infection. " 01/01/2018 - "However, contrarily to Tob, dendrimers were not protective against systemic infection caused by P. " 05/21/2019 - "Moreover, we study the efficiency of these dendrimers in combination with latency reversal agents (LRAs) against HIV-1 infection. " 12/01/2011 - "We report in this study that the dendrimer-dsiRNA treatment suppressed HIV-1 infection by several orders of magnitude and protected against viral induced CD4(+) T-cell depletion. " 01/01/2022 - "The high hemolytic activity of [G10a]2-SHa and [G10a]3-SHa dendrimers, however, limits their use for topical treatment, such as in the case of skin infection. "
4.	Glioblastoma (Glioblastoma Multiforme) 09/01/2011 - "In vitro cytotoxicity studies of free DTX, DTX-PPI and DTX-P80-PPI dendrimers were carried out using U87MG human glioblastoma cell line. " 05/19/2022 - "Furthermore, we have found that the dendrimer itself influences various parameters of the cells such as the expression of surface markers PD-L1, TIM-3 and CD47, targets for immune recognition and other biological processes suggested to be regulating glioblastoma cell invasion. " 01/01/2022 - "Surface Engineered Dendrimers: A Potential Nanocarrier for the Effective Management of Glioblastoma Multiforme." 10/01/2021 - "These results demonstrate that dendrimers are a promising targeted delivery platform to achieve effective glioblastoma treatment by improving efficacy while reducing systemic toxicities." 05/01/2021 - "Targeted systemic dendrimer delivery of CSF-1R inhibitor to tumor-associated macrophages improves outcomes in orthotopic glioblastoma."
5.	Neuroinflammatory Diseases 07/30/2009 - "The improved efficacy of the conjugate, when combined with the intrinsic neuroinflammation-targeting ability of the PAMAM dendrimers, may provide new opportunities for in vivo applications." 04/27/2018 - "Systemically administered dendrimers have been shown to localize in activated glial cells, which mediate neuroinflammation in the CNS. " 10/01/2017 - "Brain penetration (measured by drug CSF/serum level) of G6 dendrimers correlated with the severity of neuroinflammation observed. " 03/22/2016 - "We then used this model to analyze the dynamics of microglial migration and their interactions with dendrimers in the presence of neuroinflammation. " 03/22/2016 - "Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation."

Related Drugs and Biologics

1.	Poly(amidoamine)
2.	Micelles
3.	Liposomes (Liposome)
4.	Polymers
5.	Doxorubicin (Adriamycin)
6.	Small Interfering RNA (siRNA)
7.	carbosilane
8.	Peptides (Polypeptides)
9.	Paclitaxel (Taxol)
10.	Cysteine (L-Cysteine)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intravenous Administration
4.	Precision Medicine
5.	Quantum Dots (Quantum Dot)