Abstract | BACKGROUND: METHODS: In a dog model, the number of meal-induced TLESRs was determined after intravenous (0.03, 0.1, 0.3, and 1 mg kg-1 ) and oral (1, 3, and 10 mg kg-1 ) doses of mavoglurant with reference to vehicle. In a multicenter, randomized, double-blind, placebo-controlled, three-period crossover study, the incidence of meal-induced reflux episodes was assessed by esophageal impedance monitoring after single, oral doses of mavoglurant (50 and 400 mg) or baclofen (40 mg) in 30 patients with moderate to severe GERD. KEY RESULTS: In dogs, mavoglurant reduced the number of TLESRs after intravenous and oral administration. In patients with GERD, the incidence of postprandial reflux episodes was significantly lower at a dose of 400 mg mavoglurant (-37.5% ; 90% confidence interval [CI]: -57.8, -17.2), whereas there was no significant difference at 50 mg of mavoglurant compared to placebo. A significantly lower incidence of reflux episodes was also noted with the active comparator baclofen (-50.3%; 90% CI: -66.2, -34.3), thereby validating this study. CONCLUSIONS AND INFERENCES: These data suggest a potential clinical benefit of mGluR5 antagonists such as mavoglurant in patients with GERD, particularly in those with persisting symptoms despite treatment with proton pump inhibitors.
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Authors | M-L Rouzade-Dominguez, N Pezous, O J David, R Tutuian, S Bruley des Varannes, J Tack, P Malfertheiner, H-D Allescher, M Ufer, A Rühl |
Journal | Neurogastroenterology and motility
(Neurogastroenterol Motil)
Vol. 29
Issue 8
(Aug 2017)
ISSN: 1365-2982 [Electronic] England |
PMID | 28337838
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | © 2017 John Wiley & Sons Ltd. |
Chemical References |
- GRM5 protein, human
- Indoles
- Receptor, Metabotropic Glutamate 5
- mavoglurant
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Topics |
- Administration, Intravenous
- Administration, Oral
- Adolescent
- Adult
- Aged
- Animals
- Dogs
- Double-Blind Method
- Esophageal Sphincter, Lower
(drug effects, physiopathology)
- Female
- Gastroesophageal Reflux
(drug therapy, physiopathology)
- Humans
- Incidence
- Indoles
(administration & dosage)
- Male
- Middle Aged
- Postprandial Period
- Receptor, Metabotropic Glutamate 5
(antagonists & inhibitors)
- Treatment Outcome
- Young Adult
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