Impact of Maintenance Therapy for Patients with Non-small Cell Lung Cancer in a Real-world Setting.

Abstract

BACKGROUND:

The purpose of this study was to explore the role of maintenance therapy for patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting.

PATIENTS AND METHODS:

This was a prospective observational cohort multicenter study. Eligible patients were observed from initiation of first-line platinum-based chemotherapy until final follow-up.

RESULTS:

Between 2010 and 2011, a total of 864 patients were enrolled in this study. The primary study population was 396 patients who had progressive disease during observation after first-line chemotherapy without maintenance. Of these, 113 patients (29%) did not receive second-line therapy. In contrast, only 18% of patients who had progressive disease during maintenance therapy missed second-line therapy. Overall survival of patients without maintenance who received second-line therapy was similar to that of those who received maintenance, but no second-line therapy.

CONCLUSION:

Maintenance therapy for patients with advanced NSCLC might be an appropriate strategy to maximize the chance of receiving more active therapy.

• Authors: Kiyotaka Yoh, Yasushi Goto, Yoichi Naito, Kazuma Kishi, Kiyoshi Mori, Katsuyuki Hotta, Yukio Hosomi, Kazuhiko Yamada, Chiharu Tanai, Yoshio Tomizawa, Akira Inoue, Yoshinori Hasegawa, Makoto Nishio, Yasuo Ohashi, Hideo Kunitoh
• Journal: Anticancer research (Anticancer Res) Vol. 37 Issue 3 Pg. 1507-1513 (03 2017) ISSN: 1791-7530 [Electronic] Greece
• PMID: 28314326 (Publication Type: Journal Article, Multicenter Study, Observational Study)
• Copyright: Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Organoplatinum Compounds
• Pemetrexed
• Bevacizumab
• nedaplatin
• Carboplatin
• Paclitaxel
• Cisplatin

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bevacizumab (administration & dosage)
• Carboplatin (administration & dosage)
• Carcinoma, Non-Small-Cell Lung (drug therapy, mortality)
• Cisplatin (administration & dosage)
• Disease Progression
• Female
• Humans
• Lung Neoplasms (drug therapy, mortality)
• Male
• Middle Aged
• Multivariate Analysis
• Organoplatinum Compounds (administration & dosage)
• Paclitaxel (administration & dosage)
• Pemetrexed (administration & dosage)
• Prospective Studies
• Research Design
• Treatment Outcome