[Analysis of short-term respiratory adverse events in 183 bronchial thermoplasty procedures].

Abstract

Objective: To analyze the short-term (3 weeks) adverse respiratory events after bronchial thermoplasty(BT) in patients with severe asthma. Methods: The China-Japan Friendship Hospital recruited 62 patients with severe asthma for BT treatment from March 2014 to July 2016, with a total of 183 BT procedures. The data of adverse respiratory events within 3 weeks after procedure were collected to analyze the factors that might potentially influence the occurrence of adverse events. Results: Forty-three patients (69.4%) experienced adverse respiratory events within 3 weeks after treatment. Totally 153 adverse respiratory events occurred after 87 procedures(47.5%). The main adverse events were cough (15 events, 8.20%), sputum production (37 events, 20.22%), temporary PEF reduction (37 events, 20.22%), chest distress (12 events, 6.56%), blood in sputum (11 events, 6.01%), asthma exacerbation (10 events, 5.46%), and pneumonia(6 events, 3.28%). Most events were relieved or resolved with standard therapy in 1 week. No severe adverse events including tracheal intubation, malignant arrhythmias or death occurred within 3 weeks after procedure. The baseline eosinophil percentage in induced sputum and blood, operation times, and preoperative FEV(1) (% predicted) might influence the occurrence of adverse events after treatment. Patients with preoperative FEV(1) (% predicted) ≥60% had lower risk of adverse events. Conclusion: BT showed a good security profile in treating patients with severe asthma within 3 weeks after procedure.

• Authors: Y Nong, J T Lin, N Su, X Chen, Q Zhao, C Y Han, R F Qiu
• Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (Zhonghua Jie He He Hu Xi Za Zhi) Vol. 40 Issue 3 Pg. 176-181 (Mar 12 2017) ISSN: 1001-0939 [Print] China
• PMID: 28297811 (Publication Type: Journal Article)

Topics

• Adult
• Asthma (surgery)
• Bronchi (pathology, surgery)
• China
• Cough (complications)
• Electric Stimulation Therapy (adverse effects, methods)
• Female
• Forced Expiratory Volume
• Humans
• Hyperthermia, Induced
• Leukocyte Count
• Male
• Muscle, Smooth (surgery)
• Respiratory Function Tests
• Sputum
• Treatment Outcome