Memory B cells in Guillain-Barré syndrome.

Abstract

IgG autoantibodies against gangliosides show the highest titers at the disease onset of axonal Guillain-Barré syndrome (GBS), in which there are no IgM anti-ganglioside antibodies. We hypothesized that memory B cells take part in the development of producing IgG autoantibodies. In this study, we analyzed the memory B cells in patients with GBS using flow cytometry. There was significantly higher percentage of memory B cells in patients with GBS than the healthy controls. The Spearman correlation analysis demonstrated that increased percentage of memory B cells was positively correlated with the clinical severity of the patients with GBS. Our study provides the evidences that memory B cells may be involved in mechanism of GBS.

• Authors: Qian Wang, Chunye Xing, Yanlei Hao, Qiguang Shi, Ziyou Qi, Zhanyun Lv, Yan Song, Peng Xu, Xungang Feng, Lili Zhang, Yong Zhang, Yuzhong Wang, Nobuhiro Yuki
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 305 Pg. 1-4 (04 15 2017) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 28284328 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Antigens, CD

Topics

• Adolescent
• Adult
• Aged
• Analysis of Variance
• Antigens, CD (metabolism)
• B-Lymphocytes (metabolism, pathology)
• Female
• Flow Cytometry
• Guillain-Barre Syndrome (blood, immunology, pathology)
• Humans
• Male
• Middle Aged
• Young Adult