Abstract | LEARNING OBJECTIVES: METHOD: This systematic review examined all randomized, placebo-controlled trials of pharmacotherapy for ADHD in adult and adolescent SUD patients. RESULTS: The number of studies is limited, and several studies are hampered by qualitative flaws. The results, in general, are inconclusive for most medications studied, but more recent trials using psychostimulants in robust dosing have demonstrated significantly positive results. CONCLUSION: In reviewing these trials, possible explanations relating to the particular characteristics and problems of this complex patient group are discussed. Several factors, including ADHD symptom severity, psychiatric comorbidity, persistent drug use, choice of medication, and concomitant psychosocial intervention, influence study results. Taking these factors into account may improve the likelihood of detecting significant effects in future research, as the recent positive trials have indicated, and may help in the appropriate selection of pharmacotherapy in clinical practice.
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Authors | Pieter-Jan Carpentier, Frances R Levin |
Journal | Harvard review of psychiatry
(Harv Rev Psychiatry)
2017 Mar/Apr
Vol. 25
Issue 2
Pg. 50-64
ISSN: 1465-7309 [Electronic] United States |
PMID | 28272130
(Publication Type: Journal Article, Review, Systematic Review)
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Topics |
- Attention Deficit Disorder with Hyperactivity
(drug therapy)
- Diagnosis, Dual (Psychiatry)
- Humans
- Substance-Related Disorders
(drug therapy)
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