Second re-irradiation for DIPG progression, re-considering "old strategies" with new approaches.

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an aggressive infiltrative glioma for which no curative therapy is available. Radiation therapy (RT) is the only potentially effective intervention in delaying tumor progression, but only transiently. At progression, re-irradiation is gaining popularity as an effective palliative therapy. However, at second progression, exclusive symptomatic treatment is usually offered. Here we report two patients with DIPG at second progression who were treated with a second re-irradiation course with good response. Importantly, treatment was well tolerated with no irradiation associated acute toxicity identified.

• Authors: Andres Morales La Madrid, Vicente Santa-María, Ofelia Cruz Martinez, Jaume Mora, Patricia Puerta Roldan, Antonio Guillen Quesada, Mariona Suñol Capella, Carmen de Torres Gomez-Pallete, Alvaro Lassaletta, Normand Laperriere, Salvador Villà, Eric Bouffet
• Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (Childs Nerv Syst) Vol. 33 Issue 5 Pg. 849-852 (May 2017) ISSN: 1433-0350 [Electronic] Germany
• PMID: 28251325 (Publication Type: Case Reports, Journal Article)

Topics

• Brain Stem Neoplasms (diagnostic imaging, radiotherapy)
• Child
• Child, Preschool
• Disease Progression
• Female
• Glioma (diagnostic imaging, radiotherapy)
• Humans
• Male
• Re-Irradiation (methods)